None listed
Conditions
Brief summary
The primary aims of this project are to investigate the effects of changes in the levels of perceived stress on the relationship between post-stroke fatigue and quality of life and to explore the relationship between perceived stress and post-stroke fatigue. The secondary aims of the project are to explore the relationship between post-stroke fatigue and cognitive function and profile the expression of circulating microRNAs in post-stroke fatigue. The objectives of the study are to measure the baseline and follow-up perceived stress, fatigue, cognitive function and quality of life among 65 recruited stroke survivors over a period of three months and investigate the effects of the change in the level of perceived stress on the relationship between post-stroke fatigue and quality of life. We will also explore the correlation of post-stroke fatigue and perceived stress and the correlation of post-stroke fatigue and cognitive function. From collected blood samples we will profile and identify circulating microRNAs in post-stroke fatigue. The hypothesis of this project is that: 1. The increase in the level of perceived stress significantly increases the detrimental effect of post-stroke fatigue on quality of life in stroke survivors; 2. The increase in the level of perceived stress significantly increases the level of fatigue over a period of three months.
Interventions
Observation of self-reported measures of stress, fatigue, resilience and quality of life and cognitive function assessment (CANTAB) in first time ischemic or hemorrhagic stroke survivors over a period of three months. Participants will take part in a total of four interviews. The first (baseline) and final measures will occur three months apart and consist of a 1 - 1.5 hour face-to-face interview at the participants rehab facility at Baillie Henderson Hospital. These will include use of the perc
Observation of self-reported measures of stress, fatigue, resilience and quality of life and cognitive function assessment (CANTAB) in first time ischemic or hemorrhagic stroke survivors over a period of three months. Participants will take part in a total of four interviews. The first (baseline) and final measures will occur three months apart and consist of a 1 - 1.5 hour face-to-face interview at the participants rehab facility at Baillie Henderson Hospital. These will include use of the perceived stress scale questionnaire, fatigue assessment scale questionnaire, quality of life short form-36 questionnaire, brief resiliency scale and CANTAB. Two additional interviews will be conducted over the phone one month apart between the initial and final interview. These will consist of the fatigue assessment scale questionnaire and perceived stress scale questionnaire only and are estimated to take between 10 to 20 minutes. In addition to the data collected at interview, de-identified clinical details relevant to the participants stroke event and treatment will be collected from the patient records held by the Health Service. This will include anthropometrics, stroke related clinical details, blood investigations and cardiovascular comorbidities. These clinical details will be specific to the acute stroke care and include clinical details of the stroke event including patient history collected at this point, in addition to clinical details pertaining to acute stroke care which occurs in the three months following stroke event.
Sponsors
University of Southern Queensland
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
First time ischemic or haemorrhagic stroke survivors, over three months post-stroke and under three years post-stroke with sufficient grasp of the English language to complete questionnaires.
Exclusion criteria
Stroke survivors who are highly dependent such that they would not be able to participate in interview, or with patient history of multiple stroke events, or for whom stroke event occurred less than 3 months or more than 3 years ago or stroke survivors with insufficient grasp of the English language or aphasia to the extent that questionnaire could not be completed will be excluded.
Outcome results
None listed