Effects of compression of front of chest on mechanically ventilated patients with breathing machine

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Hypothesis of this study is application of anterior chest wall compression on mechanically ventilated patients will prevent ventral lung overdistention. We aim to examine changes in respiratory system compliance, oxygenation, ventilation and CT changes in lungs after applying anterior chest wall compression in mechanically ventilated patients We intend to enrol 10 patients in this single centre study. This trial will be conducted in the Southern Adelaide Local Health Network, Intensive and Critical Care Unit, Flinders Medical Centre. Screening and Recruitment Patients will be referred by treating ICU clinicians. Referral will be made as soon as possible after admission for patients who are intubated and ventilated Consent will be sought prior to enrolment Intervention Patient will have a 100 gm/kg weight placed on the anterior chest wall, while in supine position. The weight will be placed on the patients’ chest wall for 10 minutes and then removed. A number of measurements will be recorded before and after the procedure. Similar intervention repeated during CT chest. Device: weight on the anterior chest of the patient (soft and smooth weight (saline bags) placed and secure around each hemithorax) After enrolment, each patient will be treated as follows: Patients will be sedated and paralysed while mechanical ventilation settings will be kept unchanged over the course of the entire study. Initial baseline in the lying on the back ( Supine) position (T0) 10-minute period in supine position with 100 gm/kg soft and smooth weight (saline bags) placed and secure around each hemithorax (T1) In case of drop of oxygen level ( SPO2) , increase in delivered oxygen ( FiO2) will be allowed to achieve the previously described oxygen target. During the study, each patient will undergo standard ICU monitoring:

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