None listed
Conditions
Brief summary
Mycoplasma genitalium and Chlamydia trachomatis are two of the most common sexually transmitted bacteria. Doxycycline is an antibiotic that is very effective for treating C. trachomatis and it is also used for M. genitalium. Doxycycline reduces the bacterial load of M. genitalium and can help to improve M. genitalium cure when taken before a second antibiotic. Current treatment guidelines recommend 7 days of doxycycline before starting the second antibiotic for M. genitalium. However, it is possible that taking the doxycycline for less than 7 days is just as effective. To determine if the duration of doxycycline treatment can be shortened without any impact of overall treatment efficacy, we need to understand how the amount and viability (if the bacteria is alive or dead) of M. genitalium and C. trachomatis changes each day during doxycycline treatment. Therefore, this study aims to determine the impact of doxycycline on the: 1. bacterial load of M. genitalium and C. trachomatis over 7 days in men attending a sexual health service 2. viability of M. genitalium and C. trachomatis over 7 days in men attending a sexual health service 3. urethral microbiota composition
Interventions
This is a prospective observational study designed to determine the impact of doxycycline (100mg orally twice daily for 7 days) on urethral M. genitalium and C. trachomatis organism load and viability. Participants will be individuals with a known or suspected urethral M. genitalium and/or C. trachomatis infection who receive doxycycline as part of their standard treatment. Participants will be prescribed doxycycline 100mg twice daily for 7 days regardless of whether they choose to enrol in this
This is a prospective observational study designed to determine the impact of doxycycline (100mg orally twice daily for 7 days) on urethral M. genitalium and C. trachomatis organism load and viability. Participants will be individuals with a known or suspected urethral M. genitalium and/or C. trachomatis infection who receive doxycycline as part of their standard treatment. Participants will be prescribed doxycycline 100mg twice daily for 7 days regardless of whether they choose to enrol in this study or not. Interested participants will be referred to the research team following their clinical consultation. Participants will provide one urine sample prior to commencing doxycycline treatment (Day 0 sample). The Day 0 sample will be collected on the day of recruitment at Melbourne Sexual Health Centre. Participants will then be provided with a study kit and asked to self-collect one urine sample each day at home (Day 1 - Day 7) for the duration of their doxycycline treatment. A total of 8 urine samples will be collected by each participant. Participants will be asked to complete a study diary each day (Day 0 -Day 7) for the duration of their doxycycline treatment outlining if and when they, a) took each dose of doxycycline and the approximate dose time, b) collected their urine sample and indicate time of collection. The diary will take approximately 2 minutes to complete.
Sponsors
Monash University
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Individuals attending Melbourne Sexual Health Centre (MSHC) will be eligible if they fulfil all the following criteria: • Are prescribed doxycycline 100mg PO twice daily for 7 days for one of the indications below: - men attending MSHC with NGU who receive presumptive doxycycline treatment, or - men attending MSHC for doxycycline treatment (100mg PO twice daily for 7 days) for known or presumed/likely M. genitalium or C. trachomatis urethral infection, or - men attending MSHC for a urethral M. genitalium test of cure with urethral symptoms and receive presumptive doxycycline treatment, or - men attending MSHC as a sexual contact of M. genitalium or C. trachomatis with urethral symptoms in whom doxycycline is presumptively prescribed • Are aged 18 years and older • Are willing to participate in research • Can understand and comply with study procedures
Exclusion criteria
Individuals will be ineligible if they fulfil any of the following criteria: • Are currently taking or have been prescribed any antibiotics in addition to doxycycline on the day of enrolment. • Are not fluent in English • Are unwilling or unable to comply with study procedures
Outcome results
None listed