None listed
Conditions
Brief summary
The aim of this study is to explore the long-term pain relieving effect after receiving ketamine infusions. There is a need to monitor the psychological, social and functional outcomes of patients receiving this treatment. We hypothesise that ketamine infusions will improve the pain experience for those with chronic refractory pain. Your pain specialist will determine if you are eligible to participate based on your symptoms. You will need to sign a consent form prior to any further information being collected. After this you will need to complete a baseline questionnaire asking about your history with ketamine infusions as well as some common pain, psychological and social measures. You will receive three burst ketamine infusions lasting 4 hours, 2-3 weeks apart. At the end of the infusion you will be asked to complete several questionnaires about your pain as well as some information regarding any side effects experienced. At two months and three months after your course of burst ketamine treatments you will need to complete a set of questionnaires again on pain and psychosocial measures. At each point the questionnaires will take you about 30 minutes and you have the option to complete the majority of them online via email in order to make the process more convenient.
Interventions
Three consecutive subcutaneous burst ketamine infusions of four hours of a total
dose of 1.5mg/kg (based on lean body weight), 2-3 weeks (depending on patient and bed availability) apart for chronic pain in an outpatient care setting. Non-attendance of intervention will be noted on study record at the time.
Sponsors
Prince of Wales Hospital - Pain Management Department
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Australian adults aged 18+ with chronic refractory pain of >6 months classified as: - Complex regional pain syndrome - Chronic widespread body or nociplastic pain - Neuropathic pain (central, peripheral and mixed)
Exclusion criteria
Aged less than 18 - Unable to speak, read or write in English - Contraindications or known allergy to ketamine o Uncontrolled hypertension o Significant coronary disease o Severe liver dysfunction o Pregnancy/lactation - Patients with severe and unstable psychological or psychiatric conditions e.g. major psychosis or suicidality - Patients who have had a major interventional pain procedure (i.e., spinal cord stimulator or intrathecal drug infusion) - Patients with ongoing legal litigation or proceeding regarding their pain condition - Patients with a known drug dependency or substance use disorder related to ketamine or other psycho-stimulant drugs
Outcome results
None listed