None listed
Conditions
Brief summary
Exposure to ground-level ozone impairs lung function and induces systemic inflammation. Outdoor exercise is advocated for both its physical and mental health benefits, yet exercising in air pollution induces an array of pathophysiological responses and shown to be related to cognitive decline. Blackcurrants contain high levels of polyphenols that may mitigate the damaging effects of ozone on lung inflammation, and positively influence mood and cognition. The exercising athlete is more susceptible to the influence of air pollution due to increased ventilation, and breathing velocity transporting pollutants further into the respiratory tract. The objective of this study is to see if 7 day supplementation of blackcurrant powder reduces respiratory symptoms and lung inflammation, and assists exercise performance.
Interventions
Blackcurrant powder supplementation and ozone exposure. Healthy participants will supplement with a proprietary blackcurrant powder (Arepa) before undergoing an exercise trial under conditions of ozone exposure. Participants will consume either blackcurrant (BC) or placebo (PL) for seven days prior to completing a cycling protocol on a cycle ergometer in a chamber with ozone set to 0.25 ppm. Treatments (BC or PL) will be administered in purple, berry flavoured gelatine capsules at a dose of 4.3 mg/kg body weight. Subjects will take their prescribed dose daily orally for a period of 7 days before reporting to the lab for testing. Participants will be oversupplied with capsules and a countback will be used to determine adherence to the supplement protocol. Participants will complete a preload protocol of 10 min @ 50%, 10 min @ 60% and 5 min @ 70% peak power output (PPO) followed by a 10 min rest. They will then complete a 4 km time trial (TT) as fast as possible. The PPO for the preload will be obtained from a VO2 max test conducted at the first visit and familiarisation trial. There is a 2-week washout before the next supplementation period. All exercise sessions (with the exception of the VO2 and familiaristaion) will be performed under ozone (0.25 ppm) conditions. Participants will be monitored at all times throught the entire study progress. Cycling data (power, distance, cadence, time) will be automatically recorded by the ergometers associated software). Metabolic data will be collected using breath-by-breath analysis using a metabolic cart.
Sponsors
Study design
Eligibility
Inclusion criteria
Highly-trained male cyclists with a training history of > 2 years, no chronic health conditions or respiratory conditions (i.e. asthma or exercise-induced asthma or breathlessness), no acute respiratory illness within the last month, no medications that affect respiratory, cardiovascular or immune function, and be restricted to males over 18 years of age.
Exclusion criteria
None