None listed
Conditions
Brief summary
People with prediabetes have impaired glucose tolerance and a 70% chance of progressing to type 2 diabetes mellitus during their lifetime. Early detection of prediabetes and introduction of appropriate interventions can reverse symptoms and delay the onset of T2DM, improving quality of life and health outcomes. Foods rich in polyphenols and other bioactive compounds can improve blood glucose control in healthy subjects and people living with T2DM. Beetroot is high in both dietary nitrate and phytochemicals. Nitric oxide can be derived from dietary nitrate and helps mediate glucose uptake in the intestines and skeletal muscle, meaning it has an important role in regulation of blood glucose. Blackcurrants are high in the anthocyanin subclass of polyphenols which may modify blood glucose regulation through increasing insulin sensitivity. Previous research has shown that regular consumption of foods high in anthocyanins and polyphenols such as black tea and berries can improve biomarkers of glycaemic control and glucose metabolism such as 2-h postprandial glucose, HbA1c, fasting insulin, fasting blood sugar and insulin sensitivity. Furthermore, chronic supplementation with dietary nitrate has been shown to improve insulin sensitivity and glucose control in a rat model, however we are unaware of robust studies being conducted in a chronic setting in humans. This project will be conducted at Massey University and is an intervention trial consisting of four arms. The aims of the project are: - To investigate the impact of chronic supplementation of beetroot and blackcurrant compounds on measures of metabolic syndrome and glucose metabolism such as HbA1c, fasting blood sugar and lipid profiles in people with prediabetes. We hypothesise that 12 weeks of supplementation of blackcurrant anthocyanins or beetroot compounds will improve HbA1c and measures of metabolic syndrome compared to placebo.
Interventions
Participants will receive beetroot juice, blackcurrant juice, a mix, or placebo daily for 12 weeks. The beetroot juice (~67g made up to 200ml) will contain 600mg of nitrate, the blackcurrant juice (~9g made up to 50ml) 300mg of anthocyanins and the mix (~76g made up to 200ml) will contain both 600mg of nitrate and 300mg of anthocyanins.
The intervention drinks will be made up by an independent randomisation officer and participants will be asked to make the dilutions at home to decrease the qua
Participants will receive beetroot juice, blackcurrant juice, a mix, or placebo daily for 12 weeks. The beetroot juice (~67g made up to 200ml) will contain 600mg of nitrate, the blackcurrant juice (~9g made up to 50ml) 300mg of anthocyanins and the mix (~76g made up to 200ml) will contain both 600mg of nitrate and 300mg of anthocyanins. The intervention drinks will be made up by an independent randomisation officer and participants will be asked to make the dilutions at home to decrease the quantity of juice they must store. Adherence will be monitored by an online compliance diary to filled out weekly by the participants using Qualtrics survey software.
Sponsors
Massey University School of Health Sciences
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
• 30-65 years of age • BMI 18.5 - 40.0 kg/ m2 • HbA1c 41-49 mmol/ mol • Fasting glucose > 5.6 mmol/ L • Not taking any medications that include blood glucose/sugar lowering prescriptions • Not pregnant or breastfeeding • Not allergic to beetroot or blackcurrant • Non-smoker • Able to communicate well in English
Exclusion criteria
• Use insulin • Chronic kidney disease • Significant weight loss in previous 12 months • Regularly participating in >5hrs exercise weekly • On strict dietary restrictions • Other medical factors that may affect study
Outcome results
None listed