Evaluating the vitamin E from palm oil on immune response to flu vaccine

Conditions

None listed

Brief summary

Having a healthy immune system is very crucial so that our body is prepared to fight infections at any time. Healthy volunteers will be asked to take soft gels containing palm vitamin E or placebo for 56 days and they will receive a single shot of flu vaccine on day 28. The study aims to show that daily supplementation of palm vitamin E can boost host immune system so that we may be able to fight infectious agents better and have a better quality of life.

Radhakrishnan AK, Ahmad B, Selvaduray KR, Abdul Hafid SR, Palanisamy UD, Zsien Zhin C.

2024-02-22

10.12688/f1000research.137005.1

Interventions

Healthy volunteers will be randomly assigned to one of five study groups i.e. daily oral supplementation with tocotrienol-rich fraction (TRF) sofgels [50 mg, 100 mg, 200 mg or 400 mg] for 8 weeks. All subjects will receive a single intramuscular injection of flu vaccine in their arm at the end of week 4 (Day 28) and will continue with the same supplementation for another 4 weeks. The flu vaccine that we plan to use for this study is the Vaxigrip Tetra Influenza Vaccine Types A &B All subjects

Healthy volunteers will be randomly assigned to one of five study groups i.e. daily oral supplementation with tocotrienol-rich fraction (TRF) sofgels [50 mg, 100 mg, 200 mg or 400 mg] for 8 weeks. All subjects will receive a single intramuscular injection of flu vaccine in their arm at the end of week 4 (Day 28) and will continue with the same supplementation for another 4 weeks. The flu vaccine that we plan to use for this study is the Vaxigrip Tetra Influenza Vaccine Types A &B All subjects will be asked to bring along the bottles with the supplements as a way of monitoring compliance

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

18-60 years-old Healthy and free of diseases (biochemical tests) Do not have any chronic conditions (e.g. metabolic diseases, diabetes, cancer) Not on any long-term treatment/medication Not taken any vitamin E supplements for the past 3-months (low plasma vitamin E) Non-smoker Not received any flu vaccination in the last 12-months (low antibody to influenza vaccine) Normal to overweight bodyweight

Exclusion criteria

Have some health-related problems (e.g. flu, fever, allergy) Organ failures Obese Pregnant (females) Breast-feeding (females)

Outcome results