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Treatment of postoperative pain after laparoscopic cholecystectomy

Comparison of ultrasound guided thoracic paravertebral block and erector spinae plane block for postoperative analgesia after laparoscopic cholecystectomy

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000831785
Enrollment
102
Registered
2022-06-14
Start date
2021-03-01
Completion date
2021-05-31
Last updated
2022-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In recent years, many regional anaesthesia techniques have become popular to avoid the use of opioid analgesic drugs because of their negative effects in the treatment of postoperative pain. One of them, TPVB was described by Sellheim in 1905 and replaced by Kappis with a technique comparable with modern-day use. Another regional anaesthesia technique used in abdominal surgeries is ESPB, which is a new technique developed for acute and chronic thoracic pain, defined by Forero et al. in 2016. As an alternative to paravertebral block application for postoperative analgesia in LC, it is seen that it is applied with single or multiple injections at ESPB thoracic levels. Our hypothesis is that ESPB is as effective as TPVB in reducing postoperative pain after laparoscopic cholecystectomy.

Interventions

Thoracic Paravertebral Block: Thoracic paravertebral block is the technique of injecting local anesthetic along side the thoracic vertebra close to where the spinal nerves emerge from the intervertebral foramen. This produces unilateral, segmental, somatic, and sympathetic nerve blockade, which is effective for anesthesia and in treating acute and chronic pain of unilateral origin from the chest and abdomen. (https://www.nysora.com/regional-anesthesia-for-specific-surgical-procedures/abdomen/tho

Thoracic Paravertebral Block: Thoracic paravertebral block is the technique of injecting local anesthetic along side the thoracic vertebra close to where the spinal nerves emerge from the intervertebral foramen. This produces unilateral, segmental, somatic, and sympathetic nerve blockade, which is effective for anesthesia and in treating acute and chronic pain of unilateral origin from the chest and abdomen. (https://www.nysora.com/regional-anesthesia-for-specific-surgical-procedures/abdomen/thoracic-lumbar-paravertebral-block/) After the most prominent C7, processus spinosum in the cervical region was determined by palpation with the patients in a sitting position with their head slightly tilted forward, the relevant area was cleaned, we marked caudally one by one under US guidance. And 2,5-3 cm lateral of the T8 spinous process was marked as the injection point. At the needle insertion site, 2 mL of 2% lidocaine was infiltrated into the subcutaneous tissue. After placing the linear US probe on the marked area for paravertebral block application in the longitudinal plane, consecutive transverse processes and the pleura, superior costotransverse ligament, and paravertebral area were determined. With the in-plane technique, an 80 mm 22 gauge peripheral block needle was directed caudally to the cephalad, and the needle tip was advanced into the thoracic paravertebral area until the superior costotransverse ligament was passed. After confirming there was no vascular interference with aspiration, 2-3 mL of 0,9% saline was administered and ventral movement of the parietal pleura was observed to confirm the needle location, and TPVB was administered by injecting 20 mL of 0.25% bupivacaine . All TPVBs were performed by an anesthesiologist who has been working for at least 5 years. The approximate time taken to perform the thoracic paravertebral block is 10 min and performed 10 minutes before commencing surgery. The suitability of the block was evaluated with the loss of cold sensation up and down two levels in the mid-clavicular line.

Sponsors

Afyonkarahisar Health Sciences University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

Patients aged between 18 and 70 years, with the American Society of Anesthesiologists' physical status classification score (ASA) I-II, without mental or psychiatric defect, who were scheduled for elective cholecystectomy between March 2021 and July 2021 are included in the study.

Exclusion criteria

Patients outside the age range of 18-70 years, with ASA score above II, patients with local/systemic infection, severe arrhythmia, cardiac, hepatic and renal failure are not included in the study.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026