None listed
Conditions
Brief summary
The aim of this study is to evaluate the effectiveness of context-specific physical activity recommendations and activity plans for increasing physical activity in adults with a previous diagnosis of coronary heart disease. (A) The investigators hypothesise that: Primary hypothesis: 1. Participants will show a greater improvement in steps walked within 180 minutes of receiving motivational messages compared to not receiving the motivational messages. Secondary hypotheses: 2. Participants will show a greater improvement in physical activity duration and heart rate within 180 minutes of receiving motivational messages compared to not receiving the motivational messages. 3. Certain times of the day will be more effective in the proximal outcomes in those randomized to the intervention compared to those who are randomized to not receive the intervention. 4. There will be no difference in distal outcomes in Phase 1 of the study compared to Phase 2. (B) Physical activity can be tracked via Fitbit devices, which our participants will wear 24/7 during the intervention period which will be 90 continuous days at time points 4-6 and 10-12 months. (C) Baseline data will be collected for a full one month prior to initiating the intervention for the initial 4-6 months, and at month 9 (natural baseline) for the 10-12m study period. (D) Our intervention will be sent as messages (seen as notifications via the app) according to a random schedule to participants who will be randomised (to either receive or not receive the messages) at each time-point per day during the intervention period. (E) We will have a smartphone app adapted for this research and we will implement this MRT through it. (F) Data from this MRT will allow us to further design just-in-time interventions for future digital interventions. Just-in-time interventions are simply providing the right support (messages) at the right time. (G) The purpose is to provide behavioural support directly corresponding to real-time needs when participants can participate in positive behaviours. (H) Our hypothesis suggests those participants receiving the intervention messages will show an improvement in physical activity compliance, improvement in heart rate variability, and improvement in heart rate, with an overall improvement in cardiometabolic health at the 12-month time point. (I) 58 participants will be randomised for 90 days at two time points (4-6m and 10-12m).
Interventions
Behavioural: Uniform random message delivery. In this arm, the categories and timings of messages will be delivered to participants using a random schedule. The study app will be available on the Apple App Store and on the Google Play Store. A member of the research team will assist participants to download the app, create a profile, and give a brief demonstration of the various functionalities of the app. The app will have a help section where participants can find detailed written instructions and a brief video tour of the app. An example of the physical activity notification that will be sent: "Going for a walk can improve your mood and clear your mind." Specific exercises will not be specified via messages for this study (MIRTH) because it is up to the participant to decide on the physical activity type, duration, and intensity. Message delivery will be monitored by accessing app analytics to monitor delivery of app notifications to determine whether messages are delivered to participants. Physical activity can be tracked via Fitbit devices, which our participants will wear 24/7 during the intervention period which will be 90 continuous days at time points 4-6 and 10-12 months. Baseline data will be collected for a full one month prior to initiating the intervention for the initial 4-6 months, and at month 9 (natural baseline) for the 10-12m study period. Participants will receive a personalised home program based on the guidelines of the American College of Cardiology Foundation / American Heart Association to treat individuals with stable ischemic heart disease. The principles we recommend are: 1) Do moderate-intensity aerobic exercise for at least 5 days, preferably 7 days a week. Moderate-intensity aerobic exercise is defined as aerobic exercise at 64% to 76% of maximum heart rate (HRmax) (see Riebe et al. 2018) 2) Increased daily physical activity (e.g., work breaks, gardening, housework). 3) Do strength training at least two days a week. There is no specific training program for everyone, but these general principles are personalised based on baseline activity level and annual progress. Strength training is a form of physical activity that is designed to improve muscular fitness by exercising a muscle or a muscle group against external resistance, for example, body weight, free weights, dumbbells, etc. Body weight training videos of 11-minute duration will be made available. No external equipment will be required. Exercises range from step jacks, toe touching, wall push-ups, to high knee running, bicycle crunches, and high plank to low plank. The goal of all participants is to achieve at least 150 minutes of moderate intensity aerobic exercise per week. In addition to the training module, the team has also developed a series of circuit training videos for different intensities for a wide range of fitness and self-confidence levels that can be viewed at any time via the study app. The duration of the circuit training videos ranges from 11-33 minutes including a 5-minute warm up and a 5-minute cool down video. 1. Riebe D, Ehrman JK, Liguori G, Magal M. Chapter 6 General Principles of Exercise Prescription. In: ACSM’s Guidelines for Exercise Testing and Prescription. 10th Ed. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, PA: 2018, 143-179.
Sponsors
Study design
Eligibility
Inclusion criteria
1. Intervention group participants from the LIVEPLUS study (ANZCTR registration: ACTRN12620001151921). 2. Adults who can competently use a smartphone (running iOS or Android) 3. Presence of Low attenuation plaque on Coronary Computed Tomography Angiography 4. 18-80 years of age 5. BMI greater than or equal to 22.0 kg/m2 6. Have no contraindications for the LIVEPLUS study 7. Able to give full informed consent
Exclusion criteria
People from the Control group participants from the LIVEPLUS study (ANZCTR registration: ACTRN12620001151921) will be excluded. Additional exclusion criteria for the parent LIVEPLUS study are as follows: 1. History or clinical manifestation of any other significant metabolic, hematologic, pulmonary, cardio- vascular, gastrointestinal, neurologic, immune, hepatic, renal, urologic disorders, or cancer that, in opinion of the investigator, would make the candidate ineligible for the study 2. Non-MRI-compatible implanted devices or implants 3. Estimated glomerular filtration rate (eGFR) less than 30mL/kg/1.73m2 4. Inability to exercise via supine ergometer 5. Claustrophobia 6. Contraindications for adenosine: Sinus node disease (e.g. sick sinus syndrome, symptomatic sinus bradycardia), second- or third- degree heart blocks, unstable angina, bronchospasm (e.g. asthma), heart transplant recipient, history of seizure disorder 7. Contraindications for glyceryl trinitrate: Known nitrate hypersensitivity, severe anaemia, severe aortic or mitral stenosis, hypotension defined as resting systolic blood pressure equal to 89 mmHg. 8. Not suitable for CT coronary angiography due to contraindications 9. Psychiatric or behavioural problems (history of drug and alcohol abuse, eating disorder) 10. Breast feeding or pregnant women, or those intending to become pregnant before the scheduled end of the intervention 11. Concurrent participation in any other interventional study.