Skip to content

Comparison of the analgesic effect of acetaminophen, morphine and lidocaine for postoperative pain following cardiac surgery

Comparison of the analgesic effect of acetaminophen, morphine and lidocaine for postoperative pain following cardiopulmonary bypass grafting

Status
Terminated
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000686707
Enrollment
60
Registered
2022-05-11
Start date
2019-11-25
Completion date
2021-04-30
Last updated
2022-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of this study is to compare the analgesic effect of lidocaine in reducing intensity of pain in patient undergoing cardiac surgery, for coronary artery bypass graft . The comparison was done with two other analgesics, acetaminophen and morphine , as a control treatment for reducing intensity of pain in patient undergoing cardiac surgery, for coronary artery bypass graft . Intravenous administration of lidocaine provides a more satisfactory postoperative analgesia compared to the application of morphine and acetaminophen in the postoperative period

Interventions

Post operative pain management after cardiac surgery. The goal of the intervention is to reduce the intensity of pain. Two groups are included in the study as control treatment, each group has 20 patients Group 1(A) has received acetaminophen intravenous 1gr every 4 hour, for 48 hours post operative, starting immediately upon termination of anesthesia Group 2 (M) received morphine intravenous 5mg every 6 hours, for 48 hours post operative, starting immediately upon termination of anesthesia

Sponsors

University Clinical Center of Kosovo
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

All the patient planed for elective cardiopulmonary bypass surgery, ASA classification (American Society of Anesthesiologists ) II-IV

Exclusion criteria

patient rejection, unconscious patients, patients taking chronically opioids patient with renal insufficiency gr III-IV, hepatic insufficiency gr III-IV, psychiatric patients, patients allergy in acetaminophen, morphine or lidocaine respectively

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026