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Effect of Exercise on Individuals with Chronic Neck Pain and Central Sensitisation

Ability of clinical measures of central sensitisation to predict effectiveness of exercise in individuals with chronic neck pain

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000642785
Enrollment
52
Registered
2022-05-03
Start date
2022-08-26
Completion date
2024-11-25
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Clinical guidelines commonly recommend exercise as management for chronic neck pain. Several studies, however, demonstrate that exercise for chronic neck pain is effective for some, but ineffective for others. This project aims to investigate (1) the ability of clinical measures of central sensitisation to predict the effectiveness of exercise, and (2) relationship of lactate and pain sensitivity post-exercise in people with chronic neck pain. We hypothesize that higher intensity exercise, which results in higher production of lactate, will have a greater positive outcome on central sensitisation. Better understanding of these mechanisms would provide valuable insight to clinicians of the effects of exercise and lay the foundation for improved exercise prescription for chronic neck pain.

Interventions

This study is a randomised crossover trial, investigating the effect of a single-bout (30 minutes) of high intensity sub-maximal aerobic cycling exercise versus a low intensity aerobic cycling exercise. Intensity of exercise is determined by the a priori criteria of age-predicted max heart rate. High intensity exercise will have a targeted 75% age-predicted max heart rate, and low intensity will have a target of 50% age-predicted max heart rate. Intervention will be delivered in a face-to-face s

This study is a randomised crossover trial, investigating the effect of a single-bout (30 minutes) of high intensity sub-maximal aerobic cycling exercise versus a low intensity aerobic cycling exercise. Intensity of exercise is determined by the a priori criteria of age-predicted max heart rate. High intensity exercise will have a targeted 75% age-predicted max heart rate, and low intensity will have a target of 50% age-predicted max heart rate. Intervention will be delivered in a face-to-face supervised setting, by a researcher with a background in clinical exercise physiologist with 5 years experience. Participants will attend two sessions of assessments with a 1-2 week 'washout' period between each session. The study will be conducted at the Physiotherapy Rehabilitation Gym located at The University of Adelaide.

Sponsors

Dr Rutger de Zoete
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
19 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

*Chronic neck pain (3/10 pain NPRS rating) *Chronic neck pain duration >12 weeks *Age 19 to 65 years old

Exclusion criteria

*Known or suspected serious spinal pathology (e.g. metastatic, inflammatory or infective disease of the spine *Confirmed fracture or dislocation at the time of injury *Nerve root compromise (at least 2 of the following symptoms: weakness/reflex changes/sensory loss associated with the same spinal nerve) *Spinal surgery in the previous 12 months *History or presentation of psychosis, bipolar disorder, organic brain disorder or severe depression *Were taking anti-depressant or anticonvulsant medication

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 9, 2026