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Why does Good Living with Arthritis Denmark ( GLA:D®) work? A pilot study investigating the link between biomechanical factors and a successful outcome following a movement retraining program for knee osteoarthritis.

Why does Good Life with Arthritis: Denmark(GLA:D® )work? A pilot study investigating the link between biomechanical factors and a successful outcome following a movement retraining program for knee osteoarthritis.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000569707
Enrollment
33
Registered
2022-04-13
Start date
2022-05-16
Completion date
2023-02-01
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this study is to investigate the effect of a combined exercise and education intervention on biomechanics in those with knee osteoarthritis. We currently do not understand the reasons why people may improve with exercise interventions. This exploratory study will examine changes in muscle activation patterns and joint load following the GLA:D® program and see if this is related to improvements in pain or function or influences a person’s willingness to undertake surgery. GLA:D® (Good Living Arthritis Denmark) is a program for hip and knee osteoarthritis consisting of 2 education sessions and 12 physiotherapy delivered group exercise classes delivered twice weekly over 6-8 weeks. Biomechanical measurements such as knee joint loads (knee adduction moment and knee flexion moment) and muscle activation patterns (timings and co-contractions) will be measured at baseline and immediately following the GLA:D® program at 8 weeks. The relationship between biomechanical changes following the program and changes in pain and function or a person's willingness to undertake joint replacement surgery will be evaluated.

Interventions

This study will assess the biomechanical effects of a neuromuscular exercise program, GLA:D® (Good Life with Osteoarthritis in Denmark). The GLA:D® program is a multicomponent intervention consisting of the core recommended non-surgical treatments of exercise and education for those who have been diagnosed with hip or knee osteoarthritis. GLA:D® is delivered by certified GLA:D® physiotherapists and consists of 2 education sessions and 12 individual or group-based exercise sessions over a 6–8-

This study will assess the biomechanical effects of a neuromuscular exercise program, GLA:D® (Good Life with Osteoarthritis in Denmark). The GLA:D® program is a multicomponent intervention consisting of the core recommended non-surgical treatments of exercise and education for those who have been diagnosed with hip or knee osteoarthritis. GLA:D® is delivered by certified GLA:D® physiotherapists and consists of 2 education sessions and 12 individual or group-based exercise sessions over a 6–8-week period. The patient education sessions consist of 2 (60-90 minute) education sessions about osteoarthritis management delivered by a certified physiotherapist. The aim is to have Education 1 completed prior to the first exercise session and Education 2 completed within the first 2 weeks of commencing the exercise sessions. The feasibility of this will be assessed as part of this study. All participants will be provided with a GLA:D Education booklet which summarises key aspects of both education sessions. The exercise program is delivered over 12 (60 minute) sessions with a focus on a neuromuscular exercise program. Patients are encouraged to complete the program preferably in a small physiotherapy supervised group of approximately 4-6 people, however, may be completed as a home program or via telehealth. The exercise component consists of : • 10 minute warmup on exercise bike or other suitable method • lower limb circuit program (10 exercises in total) • Cool down Exercises include: • 2 abdominal/core exercises using a gym ball • 2 dynamic alignment exercises using an exercise slider • 4 lower limb strengthening exercises using TheraBand • 2 functional exercises consisting of a sit to stand and a step up requiring a sturdy chair and a step. Participants aim to perform 2-3 sets of 10-15 repetitions of each exercise. Each participant is monitored individually according to their pain intensity and progression of exercise difficulty occurs if good quality of the exercise can be maintained. Exercises are performed on both legs, with focus on the affected leg using mirror provided visual feedback (1). Participants will be provided with the GLA:D specific exercise booklet which allows recording of each session completed, pain levels pre-post session and recording of the sets/repetitions and level of exercise difficulty completed. A study specific form will be provided to each participant prior to commencing the study that allows for recording of all upcoming class and education appointments and study appointments related to their assessment in the biomechanics lab. (1) Skou ST and Roos EM. Good Life with osteoArthritis in Denmark (GLA:D): evidence-based education and supervised neuromuscular exercise delivered by certified physiotherapists nationwide. BMC Musculoskelet Disorders, 2017. 18(1): p. 72.

Sponsors

University of Canberra
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
45 Years to No maximum
Healthy volunteers
No

Inclusion criteria

1. Joint problems from the knee that have resulted in contact with the health care system 2. Clinical diagnosis of knee OA 3. Over age 45, movement-related knee pain, morning stiffness < 30 minutes and any of the following crepitus, restricted movement or bony enlargements

Exclusion criteria

1. Primary joint problems due to other reasons, for example, tumour, inflammatory joint disease such as rheumatoid arthritis, and sequelae after hip fracture 2. Other symptoms that are more pronounced than the osteoarthritis problems, for example chronic, generalized pain or fibromyalgia 3. Does not understand English (questionnaire and education sessions for GLAD Australia) 4. The index knee (most symptomatic knee) has undergone total knee replacement surgery. 5. Inability to comply with the requirements of both the GLA:D program and the pilot study Inability to attend 3-month follow up.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026