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Multiple Arterial Revascularization versus Single in a patients with coronary artery disease

Evaluation of using multiple or single arterial coronary bypass grafts on major adverse cardiac events in patients with coronary artery disease

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000552785
Acronym
MARS
Enrollment
68
Registered
2022-04-08
Start date
2020-09-24
Completion date
2026-03-27
Last updated
2022-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Multiple arterial grafts during CABG increase postoperative survival as compared to a single arterial graft, especially in the long-term period. The study purpose is demonstrate that use of 2 or more arterial grafts for elective primary surgical revascularization in patients with multivessel disease is associated with a reduction in mortality, stroke, heart attack, and repeat revascularization.

Interventions

A randomized study comparing two groups of patients undergoing coronary artery bypass grafting (CABG) at our institute. Patient first group underwent multiarterial coronary bypass surgery (left and right mammary arteries, radial artery). Materials: Two hundred patients listed for CABG Procedures: All CABGs were performed through a median sternotomy during cardiopulmonary bypass. Full heparinization was given. It anticipated to take an additional 20 minutes for multiarterial coronary bypass surge

A randomized study comparing two groups of patients undergoing coronary artery bypass grafting (CABG) at our institute. Patient first group underwent multiarterial coronary bypass surgery (left and right mammary arteries, radial artery). Materials: Two hundred patients listed for CABG Procedures: All CABGs were performed through a median sternotomy during cardiopulmonary bypass. Full heparinization was given. It anticipated to take an additional 20 minutes for multiarterial coronary bypass surgery Who: heart surgeon with 10 years experience Mode of delivery: face to face Number of times: twice / week to the surgeon performing the CABG procedure All participants will be followed for up to 12 years after the initial surgery.

Sponsors

Ministry of Science and Higher Education
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

coronary artery disease

Exclusion criteria

Concomitant surgery (valve surgery, aorta surgery)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026