None listed
Conditions
Brief summary
The purpose of this study is 1)To observe the effects of zinc supplements on lipid profile 2)To estimate the role of zinc in adjusting lipid profile and uric acid level in smokers and non-smokers 3)To evaluate the effect of zinc on cognition in smokers and non-smokers it is the open labelled non-randomized trial in which two groups of 60 participants will included one control group will be include 10 healthy non-smoker volunteers and other group interventional group consist of n= 50 participants which will divided into two sub-groups smokers group and non-smokers group and the other group non-smokers group. each sub-group consist of n=25 participants control group on their daily food and liquid intake with excercise with no zinc supplement treatment while in interventional group both sub-groups will taken 50mg of zinc gluconate once daily for 8 weeks. the primary outcomes like as lipid profile(TC,TG, LDL, HDL) and serum uric acid and secondary outcome questionnaire will be analyzed at zero day or as pre-test values and after 8 weeks again taken primary outcomes as post-test values. after that the data will be analyzed by SPSS for difference and comparative analysis through t-test
Interventions
The intervention group will sub-divided into two groups that is smokers group and non-smokers group. The smokers group include 25 smoker volunteers and non-smokers group include 25 non-smoker volunteers .These groups take Zinc Gluconate 50mg once daily for 8 weeks by oral route. Adherence to the intervention check by weekly follow-up and drug tablet pack return strategy
Sponsors
Dr. Malik Hassan Mehmood
Study design
Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1)Volunteers age range between 18 to 60 years 2)Only healthy volunteers were included in control group 3)Smoker must use 5 cigarettes per day from last 2 years 4)Participants must not receiving prescribed medication like as lipid lowering agents (fibrins, statins) and uric acid lowering agents (allopurinol) which might interfere with study protocol. 5)Participants included in experimental group were not having the history of some chronic cardiovascular disease, respiratory disease, diabetes mellitus, hepatic or renal disorder or any other severe disease.
Exclusion criteria
1)Female volunteers if pregnant, lactating or using contraceptive were excluded from the study. 2)Smokers under nicotine dependence treatment from last three months were excluded from the study. 3)Persons with decrease lipid profile, uric acid levels and normal level of plasma zinc were not participating in study. 4)Participants who were recently consuming supplements in the past three months were excluded from study 5)Persons with alcohol consumption history were not participated in study.
Outcome results
None listed