None listed
Conditions
Brief summary
"The rationale of this study is that neonatal seizure is a treatable condition and the present anticonvulsants used are not much efficient as well as not safe in neonates in controlling the seizures. Therefore, we want to compare the efficacy and adverse effects between both Phenytoin and Levetricetam which will help in finding the best drug controlling the neonatal seizures quickly with minimal adverse effects. We hypothesise that levetiracetam is more effective and safe than phenytoin in termination of seizures
Interventions
Participants will receive one loading dose levetiracetam of 5-10mg/kg intravenously over 15 minutes following identification of seizures.
This maintenance dose 10mg/kg intravenously will be started 12 hours after the first loading dose
The maintenance dose will be given once daily thereafter until termination of seizures."
Sponsors
DR KHWAJA KAMRAN WAJID
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
1 Hours to 30 Days
Healthy volunteers
No
Inclusion criteria
Neonates till 30 days of life both male/female with seizures.
Exclusion criteria
Neonates with hypoglycemia, hypocalcemia, hypomagnesemia, those who received anticonvulsants prior to enrolment, and those with major congenital malformations e.g., congenital heart defects, neural tube malformations, diaphragmatic hernia, choanal atresia, esophageal atresia, tracheoesophageal fistula, omphalocele, gastroschisis, intestinal obstruction and imperforate anus) were excluded.
Outcome results
None listed