None listed
Conditions
Brief summary
Because curcumin modulates the cell redox state and the transcription of many genes that can inhibit the activity of transcription factors influencing the intensity of oxidative stress. The main aim of the study will be to evaluate the effect of curcumin supplementation on blood prooxidant/antioxidant balance, levels of muscle damage markers and inflammatory mediators in long-distance runners. In the first stage, participants performed a running test with gradually increasing load on a treadmill (Cosmed, Germany) to assess aerobic capacity. During the test, the running speed will be increased every 3 min by 2 km/h until a running speed of 14 km/h was reached, and then the angle of the treadmill to the ground was increased until the body's individually maximum muscle workload was reached. Blood for biochemical tests was collected 3 times, i.e., before the start of the exercise test, 3-5 min after its completion and at 1 hour post-exercise restitution in each stage of the study. The subjects were then randomly divided into two groups: curcumin-supplemented and placebo. The participants took a dietary supplement (2 g a day) or placebo (2 g a day) for a period of 6 weeks. In the second stage of the study (6 weeks after starting to take the supplement or placebo) the subjects will again undergo assessment of basic anthropometric parameters and will perform a running test as mentioned above. Blood for biochemical tests will be collected same as in the first stage. Blood plasma, serum and erythrocytes were kept frozen at -80 °C for less than one month before they were analysed.
Interventions
This study is controlled, double-blind, parallel intervention trial in healthy men (amateur long distance runners). The purpose of this intervention is to evaluate the effects of 2 g curcumin supplementation on prooxidant/antioxidant balance, inflammation and exercise-induced muscle damage. The participants will take 2 capsules (500 mg each) of curcumin extract with piperine (Curcumin 500 max, Nanga, Zlotów, Poland) twice a day before meals, i.e. before breakfast and before dinner, drinking wate
This study is controlled, double-blind, parallel intervention trial in healthy men (amateur long distance runners). The purpose of this intervention is to evaluate the effects of 2 g curcumin supplementation on prooxidant/antioxidant balance, inflammation and exercise-induced muscle damage. The participants will take 2 capsules (500 mg each) of curcumin extract with piperine (Curcumin 500 max, Nanga, Zlotów, Poland) twice a day before meals, i.e. before breakfast and before dinner, drinking water, for a period of 6 weeks. According to the manufacturer's information, the content of the supplement capsule consists of: extract from long spurge standardised to 95% curcumin (500 mg) and extract from black pepper 95% (10 mg), an ingredient of the capsule (gelatin, purified water 13-17%). The study will be conducted in two phases: - in the first phase all subjects and will undergo assessment of body composition. Then all subjects will perform a running test with gradually increasing load on a moving treadmill. Blood for biochemical tests will be collected 3 times, i.e., before the start of the exercise test, 3-5 minutes after its completion and at 1 hour post-exercise restitution. The subjects will then be randomly divided into two groups: curcumin supplemented and placebo. -in the second phase of the study (6 weeks after starting the supplement or placebo), the subjects will again undergo assessment of baseline body composition and perform a running test as above. Blood for biochemical tests will be collected 3 times, i.e., before the start of the exercise test, 3-5 minutes after its completion and at 1 hour post-exercise restitution.
Sponsors
University of Physical Education in Katowice
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
Male
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria were healthy male and training experience of three years minimum.
Exclusion criteria
The exclusion criteria included the use of tobacco products, alcohol consumption, any medicines or dietary supplements in the four previous weeks.
Outcome results
None listed