None listed
Conditions
Brief summary
The purpose of this study is to compare the effect of eyelid wipes with and without Manuka honey in order to ascertain whether the Manuka honey (in the form of eyelid wipes) provides any potential benefits to patients with dry eye. Participants will be randomly assigned to use either the test eyelid wipes with Manuka honey or the control standard eyelid wipes without Manuka honey once daily for one month. Measurements of ocular signs and symptoms will be collected before and after one month of treatment, and the results between treatment groups will be compared. The hypothesis is that the eyelid wipes with Manuka honey will reduce the amount of bacteria on the eyelid more than the standard eyelid wipes, and consequently improve other signs and symptoms of dry eye.
Interventions
Eyelid wipes with Manuka honey (Blephadex Pro).
Participants will be instructed to clean their eyelids with a fresh wipe (one wipe for both eyelids), once daily in the morning for the duration of the study (one month).
Participants will be asked to return unused wipes at the follow-up visit to monitor for compliance.
Sponsors
UNSW Sydney
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Adult aged 18 years of older • Able to read and comprehend English and give informed consent as demonstrated by signing a record of informed consent • Symptoms of dry eye (OSDI questionnaire score of >12) • At least one sign of dry eye in one eye (e.g. blocked oil-producing gland on the eyelid margin, average fluorescein tear break-up time <10 seconds) • Willingness to not change usage frequency and type of any currently used products for the treatment of dry eye for the duration of the study
Exclusion criteria
• Known allergy to honey/bee products • Hard contact lens wear one month prior to baseline and during the study, or soft contact lens wear one week prior to baseline and during the study • Use of eyelid cosmetics during the study • Have autoimmune disease or other systemic disease that may have an impact on tear film properties • Use of any medication (eg. anti-inflammatory, anti-infectives or immunosuppressives) that may have an effect on ocular physiology and/or function during the study • Active eye infection • Use of Blephadex Pro eyelid wipes or any other ocular treatments (topical drops or creams) containing Manuka honey within 2 weeks prior to the Screening visit
Outcome results
None listed