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Imagery Rescripting as an adjunct treatment for depression

Assessing treatment outcomes for patients with depression attending a group cognitive behavioural therapy programme by additionally treating aversive memories with Imagery Rescripting

Status
Withdrawn
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000175774
Acronym
DEPIR
Enrollment
45
Registered
2022-02-02
Start date
2022-03-14
Completion date
2022-12-31
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Research has shown that people with depression experience poorer treatment outcomes if they have had adverse childhood experiences; and that these experiences often intrude into their thinking, and at a rate similar to that of post-traumatic stress disorder (PTSD). Although cognitive behaviour therapy (CBT) has been found to be effective in the treatment of depression, a number of people treated with CBT do not recover, or relapse during follow-up. We wish to test the efficacy of an adjunct trauma-focused therapy — Imagery Rescripting (ImRs) – for the treatment of depressed patients receiving group CBT treatment. We hypothesise adjunct ImRs treatment will lead to a superior reduction in depression symptoms compared to control conditions of individual CBT and treatment as usual.

Interventions

All participants will receive evidence based group CBT psychological intervention (Mood and Anxiety Management Programs, MAMP), consisting of one session per day of approximately 3 hours duration, from Monday to Friday (i.e. 5 sessions per week). In addition, participants will be randomly assigned to three treatment conditions. The CBT group work is undertaken in the mornings during this time and the additional individual treatment sessions would take place over the two weeks of the group prog

All participants will receive evidence based group CBT psychological intervention (Mood and Anxiety Management Programs, MAMP), consisting of one session per day of approximately 3 hours duration, from Monday to Friday (i.e. 5 sessions per week). In addition, participants will be randomly assigned to three treatment conditions. The CBT group work is undertaken in the mornings during this time and the additional individual treatment sessions would take place over the two weeks of the group program in the afternoon, with at least one day between these individual sessions. Participants will continue to receive MAMP sessions in addition to the intervention sessions for the duration of the study period. All group treatment sessions are delivered face-to-face at the Hollywood Hospital clinic. While we will aim to complete individual sessions face-to-face, this may not always be feasible in light of the current pandemic. Therefore, sessions will be carried out via telehealth in instances where face-to-face interaction is not feasible (e.g., state lockdowns, researchers needing to quarantine/isolate). Evidence suggests that both of our proposed interventions (ImRs and CBT-based interventions) can be effectively delivered via telehealth (Osenbach et al., 2013; Paulik et al., 2021). Our preferred telehealth software will be Zoom, which has been approved for use by the Australian Psychological Society. To monitor adherence to group and individuals sessions, attendance will be monitored using a client session checklist. Arm 1. Three individual 90 minute sessions utilising imagery rescripting (ImRs). ImRs is an evidence based psychological intervention for posttraumatic stress disorder. In ImRs, the patient is asked to focus on an aversive memory from their child-self perspective, identifying their thoughts, feelings and needs. Next they are then guided to imagine a different ending, such as someone intervening by stopping the abuse and caring for the needs of the child. Multiple suggestions are made until the patient identifies that the new imagined experience meets the core need of the child self in the original memory. The initial ImRs session would entail giving information on the intervention, establishing a safe place via imagery and identifying memories that would be targeting in subsequent session. The second and third session would involve rescripting identified memories as per ImRs procedure. Arm 2. Three individual 90 minute sessions utilising Cognitive Behavioural Therapy Assertiveness Training (CBT-AT). CBT is an evidence based practice that is widely used in the treatment of psychological disorders. CBT-AT supports an individual to identify and alter unhelpful thoughts, feelings and behaviours. Sessions would focus on assertive communication, looking at the individuals beliefs around assertiveness and supporting them to practice more assertive behaviour Arm 3. Treatment as usual / Delayed treatment. Participation in the group program with no additional individual sessions. however will be offered individual sessions following their six week follow up assessment. All treatment sessions will be delivered by the researchers who are in their second year of their clinical masters and who are trained in both interventions. The first cohort (2-4 participants) to be administered the assessments and intervention are treated as a trial and as such their data will not be included in the data analysis.

Sponsors

Murdoch University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Participation in the Hollywood Clinic Mood and Anxiety Management Program.

Exclusion criteria

nil

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026