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Predicting perioperative risk in patients in aged 90-100 years.

A modified Aged-Adjusted Charlson Comoribidy Index risk score in predicting perioperative outcomes in nonagenarian patients.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12622000170729
Enrollment
3103
Registered
2022-02-02
Start date
2021-04-15
Completion date
2021-07-31
Last updated
2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The Charlson Comorbidity Index (CCI) is a validated risk score for clinicians in predicting perioperative mortality and morbidity in comorbid patients. The CCI has been further refined with the Age-Adjusted Charlson Comorbidity Index (ACCI), adjusting the existing CCI score for increasing age. The ACCI has subsequently been validated in predicting short term and long-term outcomes including mortality, function outcomes and hospital length of stay across different surgical populations. The aim of this study is to assess if the ACCI is valid in patients aged greater than 90 years i.e. nonagenarians. Who is it for? You may be eligible for this study if you were aged > 90 years who underwent any surgical procedure for for any indication. Study details This study will be conducted using a review of medical records, and no patient contact is required. The study will review the medical records of nonagenarians who underwent any surgical intervention at the Austin Hospital over a 13-year period between 25 August 2008 and 8 June 2021. It is hoped that this research will help to provide a better understanding of predicting risk in nonagenarians undergoing minor and major surgery.

Interventions

In this study we will first be observing postoperative complications in patients aged 90-100 years who have undergone any surgical procedure or intervention at Austin Health between 1 January 2012 to 31 December 2019. As this is a retrospective study, there is no participant involvement. Only the de-identified hospital medical record of patients who have had surgery will be reviewed. Second, we will then assess if the age-adjusted Charlson Comorbidity Index (CCI) can be applied to the nonagena

In this study we will first be observing postoperative complications in patients aged 90-100 years who have undergone any surgical procedure or intervention at Austin Health between 1 January 2012 to 31 December 2019. As this is a retrospective study, there is no participant involvement. Only the de-identified hospital medical record of patients who have had surgery will be reviewed. Second, we will then assess if the age-adjusted Charlson Comorbidity Index (CCI) can be applied to the nonagenarian surgical population. Our study presents the validity of age-adjusted CCI for nonagenarian patients across multiple surgical and endoscopic streams, whilst proposing a modified score in improving perioperative risk assessment for this vulnerable population. The Charlson Comorbidity Index is a validated risk score for clinicians in predicting perioperative mortality and morbidity in comorbid patients. First introduced by Professor Mary Charlson and her peers in 1987, the CCI assesses comorbidity level through the number and severity of 19 pre-defined comorbid conditions. Scores are weighted accordingly for each disease and their severity. Charlson et al, subsequently established a refined tool with the Age-Adjusted Charlson Comorbidity Index (ACCI) in 1994, adjusting the existing CCI score for increasing age. The ACCI has subsequently been validated in predicting short term and long-term outcomes including mortality, function outcomes and hospital length of stay across different surgical populations. The CCI has since become one the most widely used scoring system for comorbidities by clinical researches for longitudinal studies and by point of care clinicians.

Sponsors

Austin Health - Austin Hospital - Heidelberg
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
90 Years to 100 Years
Healthy volunteers
No

Inclusion criteria

Patients aged 90-100 years undergoing any surgical or interventional procedure. All operative and anaesthetic techniques will be considered. We will include the following types of surgeries: 1. cardiac and non-cardiac surgery 2. endoscopic procedures 3. superficial skin surgery under local anaesthesia 4. any radiological intervention requiring anaesthesia 5. cardiac procedures requiring anaesthesia (insertion of permanent pacemakers, electrical cardioversion, coronary angiograms, or any coronary intervention including transcatheter aortic valve replacements) 6. cataract extractions under topical, retrobulbar, or peribulbar eye blocks.

Exclusion criteria

Any patients aged less than 90 years or great than 100 years, or a patient who does not undergo a surgical procedure.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026