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Effects of Pilates exercise on functional capacity, cancer-related fatigue, depression, salivary cortisol and quality of life among colorectal cancer survivors in Klang Valley, Malaysia.

Effects of Pilates exercise on functional capacity, cancer-related fatigue, depression, salivary cortisol and quality of life among colorectal cancer survivors in Klang Valley, Malaysia.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000163707
Enrollment
36
Registered
2022-01-31
Start date
2022-07-16
Completion date
2023-01-01
Last updated
2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Colorectal cancer survivors experience several long-term health issues such as poorer health fitness and psychological outcomes such as depression which can eventually affect their quality of life (QOL). Physical activity had been proven as a protective factor to prevent recurrence and may improve survival rate. In Malaysia, there is a lack of physical activity performed by colorectal cancer survivors and no specific exercise package has been tested among colorectal cancer survivors. Pilates exercise has been identified as a gap to be explored among colorectal cancer survivors. The role of salivary cortisol as a biomarker in this population after exercise intervention is worthy to be studied to explain the association between Pilates exercise and psychological outcomes. Therefore, this research aims to study the effectiveness of Pilates exercise on functional capacity, cancer-related fatigue, depression, salivary cortisol and its influences on QOL among colorectal cancer survivors in Hospital Canselor Tuanku Muhriz, Cheras, Kuala Lumpur using a quasi-experimental study as its study design. Thirty-six (36) colorectal cancer survivors will be allocated into either a supervised Pilates exercise group (N= 18) or a control group (N= 18). The Pilates exercise program will be conducted by a certified Pilates instructor for three sessions per week with 60 minutes per session for eight weeks. The European Organisation Research and Treatment of Cancer (EORTC) QLQ-30 and QLQ-CR29 questionnaires, Patient Health Questionnaire – 9 (PHQ-9) and Functional Assessment of Chronic Illness Therapy-Fatigue Scale questionnaires and enzyme-linked immunoassay (ELISA) will be used to assess the quality of life (QOL), cancer-related fatigue, depression, and salivary cortisol levels before and after the intervention. Meanwhile, a 6-minute walk test will be used to assess the functional capacity of the subjects. This research will add a new insight to the clinical rehabilitation impact study for colorectal cancer survivors using Pilates exercise that offers a low-impact home-based exercise that is cost-effective. The usage of this specific exercise intervention can be used in promoting physical activity among colorectal cancer survivors. This may improve their survival rate and prevent recurrence in the long term.

Interventions

Recruitment All colorectal cancer survivors who were treated and completed treatment at both study sites that met the eligibility criteria are recruited using convenience sampling. The comparability of the variables s is carried out to determine whether the study populations in both groups are similar. Next, the participants from Hospital Canselor Tuanku Muhriz will be allocated to the intervention group and participants from Hospital University Technology MARA will become the control group.

Recruitment All colorectal cancer survivors who were treated and completed treatment at both study sites that met the eligibility criteria are recruited using convenience sampling. The comparability of the variables s is carried out to determine whether the study populations in both groups are similar. Next, the participants from Hospital Canselor Tuanku Muhriz will be allocated to the intervention group and participants from Hospital University Technology MARA will become the control group. Intervention The intervention group will perform Pilates exercises with a certified Pilates instructor for 60 minutes 3 sessions per week for eight weeks. The Pilates exercise programme is a moderate-intensity exercise with a heart rate maximum is 50-60% (Algayer et al. 2008) and corresponding to a rating of perceived exertion between 12 and 13 (ACSM, 2014) adapted from the study by Cantarero-Villanueva et al. (2016). Our expert panels consisting of sports medicine specialists, Pilates instructors, colorectal surgeons and physiotherapists already verified the exercise prescription is safe as an intervention among colorectal cancer survivors by The Pilates exercise will start with a warm-up session then followed by the Pilates exercise. The Pilates exercise steps will be carried out in this study as follows; 1. One-leg stretch i. Participants are lying down in a supine position and stretch one leg. 2. One-leg circle i. Participants are lying down supine, stretching one leg and making circular movements using the stretched leg. 3. Bridging i. Participants will lie on their back with hands at sides, knees bent and feet flat on the floor under the knees. ii. Then tighten the abdominal and buttock muscles by pushing their low back into the ground before pushing up. iii. Next, they will raise their hips to create a straight line between knees and shoulders. Then, squeeze their core and pull the belly button back toward their spine. Hold for 20 to 30 seconds and then return to starting position. 4. Dead bug resting i. Participants are lying flat on their backs. ii. Extend the arms and raise their feet, knees and hips. iii. Then lower their opposite arms and legs simultaneously. iv. Repeat with the other arm and leg. 5. Saw i. Participants sit down on the exercise mat with both legs straight and arms flexed at 90 degrees. ii. Then, participants will turn their body to the left and stretch the right hand to get as close as possible to the toes. iii. This step is then repeated with the left hand. The exercise is adapted to each participant's ability and tolerance. The participants will do the exercise via online streaming at the participants' homes in a group of sixteen (16) per session. The participants will be given a booklet that consists of exercise techniques and safety measures to be followed during the exercise. (This booklet is newly designed to act as a study manual specifically for this research). Besides that, we will give a video recording showing the demonstration of the exercise to the participants to ease them in following the activity. They are also provided with a polar heart rate sensor during the exercise to monitor their heart rate. The exercise is adapted to each participant's ability and tolerance. Therefore, each participant will perform the exercise according to their capacity (i.e., stop and rest in between the steps or repetitions, drinking water). The instructor and facilitators will monitor the participants closely. The exercise is adapted to each participant's ability and tolerance. Adherence will be considered if they meet 75% of the session during the intervention period (Cantarero-Villanueva et al., 2016; Eyigor et al., 2010). The attendance for every session will be recorded in the attendance sheet by our researcher.

Sponsors

University Technology MARA
Lead SponsorUniversity

Study design

Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used) (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

1. Malaysian citizen or permanent residents age 18 to 65 years old. 2. Patients with a histologically confirmed diagnosis of colorectal cancer at Stage I, II and III treated at Hospital Canselor Tuanku Muhriz. 3. Completed all the curative treatment, surgery and chemotherapy/radiotherapy treatment within one year before the study enrollment.

Exclusion criteria

1. Colorectal cancer patients that have developed metastasis and recurrent cancer. 2. Patients diagnosed with colorectal cancer as secondary cancer. 3. Colorectal cancer patients who suffer from hereditary colorectal cancer syndrome(s). 4. Have known limitations in Activities of Daily Living (ADL); eating, bathing, getting dressed, toileting, transferring and continence. 5. Diagnosed by specialists with musculoskeletal disorders (osteoarthritis, fibromyalgia, scoliosis or lower-back pain), ischemic heart disease and metabolic disorders. 6. Diagnosed by specialists with psychiatric illness, currently using psychiatric medication or receiving treatment for depression. 7. Diagnosed by specialists having chronic fatigue syndrome or currently using medication or receiving treatment for chronic fatigue syndrome. 8. History of neurological disorders (seizures, epilepsy etc.), urological problem (incontinence), abdominal hernia, autoimmune disease (SLE, rheumatoid arthritis). 9. Patients with a colostomy.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026