None listed
Conditions
Brief summary
Parkinson's disease (PD) is a degenerative neurological disease and gait disturbance is frequently seen in individuals with PD. They demonstrate decreased speed and stride length and increased gait variability during walking. In addition to motor impairments, the impairments of cognitive and sensorimotor processing may exert further impact on dual task walking to result in increasing fall risks. The dual task walking is required for daily activities; however, such ability is even more challenging than single walking for people with Parkinson's disease. Therefore, the study aim to investigate the effects of DLPFC tDCS combined treadmill training on dual task gait performance and cortical activity in patients with PD. We hypothesized that the participants receiving 12 sessions of real DLPFC tDCS combining treadmill training will improve more on dual task walking performance and cortical activity than participants receiving sham tDCS combining treadmill training.
Interventions
Participants in both groups will receive tDCS followed by treadmill training 3 sessions a week for 4 weeks (total 12 sessions).
All the tDCS interventions will be administered by same researcher assistant. We will apply anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) of dominant hemisphere (according to EEG 10/20 system), and cathodal electrode over the contralateral supraorbital area as a reference. A constant current of 2 mA will be applie
Participants in both groups will receive tDCS followed by treadmill training 3 sessions a week for 4 weeks (total 12 sessions). All the tDCS interventions will be administered by same researcher assistant. We will apply anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) of dominant hemisphere (according to EEG 10/20 system), and cathodal electrode over the contralateral supraorbital area as a reference. A constant current of 2 mA will be applied for 20 mins in experimental group. Treadmill training includes warming up for 3 minutes, training for 25 minutes, and relaxing for 2 minutes. The speed of the treadmill during the warm-up and relaxation period is based on the participant's Borg's rating of perceived exertion (RPE) 7-9 points (very slight to very slight), and the RPE during the training period does not exceed 10~12 points (slight). -During treadmill training, all participants will be instructed and supervised by a registered physical therapist. -Session attendance, and drop out will be monitored and record by a session attendance checklist for each client.
Sponsors
Professor Ray-Yau Wang
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Inclusion Criteria: (1) diagnosed as idiopathic Parkinson's disease (PD) (2) stage 1 to 3 on the Hoehn and Yahr scale (3) ability to walk independently for at least 10 m without use of walking aids (4) stable medical condition (5) mini-mental state examination (MMSE) score of>24
Exclusion criteria
Exclusion Criteria: (1) history of diseases or conditions known to interfere with participating the study (e.g., active cancer, epilepsy or metal implants in the brain) (2) history of using central nervous system medications other than for PD, e.g. anti-epileptic or anti-depressant drugs in recent month.
Outcome results
None listed