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Promoting COVID-19 vaccination in rural Bangladesh

Identifying the most cost-effective way to large scale vaccination for COVID-19 in rural Bangladesh

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12622000068763
Enrollment
12000
Registered
2022-01-20
Start date
2022-01-24
Completion date
2022-04-30
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The idea to increase COVID-19 vaccine uptake is a very important issue and needs to be addressed at the earliest as vaccines are the only weapon that can end this terrible war against COIV-19. Efforts therefore need to be undertaken to understand what the determinants of large scale vaccine uptake are and identifying the most cost-effective channel at the earliest. Using detailed data from a large Randomized Controlled Trial from several districts in Bangladesh this study attempts to isolate the effect of each of different interventions (accessibility vis-à-vis campaign or communication intervention to address misconception) on willingness to take vaccines and actually getting vaccinated, thereby achieving large scale vaccination in a cost-effective manner.

Interventions

The objective of the proposed study is to identify the most effective strategy to promote large scale vaccination among adults in Bangladesh. Towards this end, the eligible sample of unvaccinated individuals will be randomly assigned to a control group and one of the three treatment arms. There will be three treatment groups: Information will be disseminated about the available vaccines, benefits, and costs associated with getting vaccinated via awareness campaign from a reliable source to all

The objective of the proposed study is to identify the most effective strategy to promote large scale vaccination among adults in Bangladesh. Towards this end, the eligible sample of unvaccinated individuals will be randomly assigned to a control group and one of the three treatment arms. There will be three treatment groups: Information will be disseminated about the available vaccines, benefits, and costs associated with getting vaccinated via awareness campaign from a reliable source to all the three treatment groups. While the first treatment group will receive only the information treatment, the other two treatment groups will receive additional interventions. Thus, in addition to the information campaign, the other two treatment groups will receive one of the two different interventions (accessibility vis-à-vis campaign to address misconception via an ambassador) to isolate the effect of each of the different treatments. The three different treatments that we will focus on in the proposed project are as follows: Treatment 1 (T1): Information campaign only. Treatment 2 (T2): Information campaign + Accessibility (helping them with registration/enrolment, travelling to get vaccinated, and reminding/encouraging them to get vaccinated at the right time via brief telephone reminders). The gentle and brief reminder will be provided both through a phone call as well as a SMS about two weeks after the intervention is delivered. We will help the target group with the registration procedure and will track their progress from registration to vaccination, reminding them to get vaccinated (all free of cost). They will also be provided help with identifying the nearest vaccination center and travelling to the same, and any travelling cost using the most convenient travel mode as locally available. This intervention will be provided by the staff of the NGO partner, GDRI (Global Development Research Institute), who will work closely under the supervision of the research team. Treatment 3 (T3): Information + campaign/motivation by eminent figures in the community (e.g., village leaders, teachers, doctors, etc). We will approach village leaders to identify the most respected and trusted eminent figure in their community (e.g., religious leaders, teachers, doctors) and ask him/her to campaign and propagate information to address misconceptions related to the available vaccines. To be more convincing and credible, the selected individuals should already be vaccinated or at least have registered to get vaccinated. Campaigning by eminent figures will start as soon as he/she is selected. Specifically, the selected eminent figures (we call them 'Ambassadors')will be asked to campaign and propagate specific information (in addition to basic information being provided to all) to address misconceptions related to the available vaccines. Ambassadors will speak with the unvaccinated selected individuals one-to-one by visiting them while following strict health protocols (e.g., every respondent and ambassador will wear mask, maintain 1.5 meters between individuals, open air space), and try to convince them to get vaccinated. The meeting will occur once during the campaign period (1 month) and each meeting will last for a maximum 1 hour. The campaign will be based on context-specific information and guidelines provided by the central and local government bodies and will dispel misperceptions about the disease, the available vaccines, distribution of infection and fatality rates and improve knowledge about COVID-19 prevention and transmission etc. The control group on the other hand will receive no such information campaign about the vaccines or any specific incentives. The research team will visit the participants about one month after the intervention to verify their vaccination status. They will be visited again one month after the first verification to update the vaccination status and conduct the endline and spillover surveys (which will ask randomly selected individuals from the villages about their vaccination status- to understand if the intervention also influenced other people to get vaccinated). The vaccination status will be verified using the registration information and text messages sent by the govt's department of public health confirming the dose of the vaccine and the date being vaccinated. We will select a total of 685 locations (villages), with 10-20 unvaccinated people (average 13 participants per village) from each of these locations. From each household, we will focus on adult individuals who are eligible for COVID19 vaccine free of cost and are unvaccinated. Only one participant will be recruited for the purpose of the survey and the intervention. Randomization into treatment and control groups will be done next at the village level. About 9,000 selected individuals identified from the 685 locations will be randomised (using a computer program), with 137 locations in the pure control (T0) and information campaign only (T1) arms, 205 locations in T2 and 206 locations in the T3 arm. All these changes were happened prior to enrolment commencement

Sponsors

Monash University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

About 9,000 unvaccinated individuals (as of May 15, 2022) aged 18-65 years (one from each household) randomly selected from 685 different locations (both rural and urban) across several districts in Bangladesh.

Exclusion criteria

Individuals aged below 18 years Individuals aged above 65 years Those not able to give informed consent Those not visiting relatives in the study area and not living there for the next 9 months

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026