Skip to content

Evaluation of Placentas of Women with Endometriosis

Morphological Evaluation of Placentas of Pregnant Women with Endometriosis

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12621001641886
Enrollment
40
Registered
2021-11-30
Start date
2021-12-15
Completion date
Unknown
Last updated
2021-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Endometriosis is a common gynecological disease characterized with presence of ectopic endometrial tissue outside the uterus. Recent literature about pregnancy outcomes in women with endometriosis revealed that some adverse outcomes are more common in this special population. Placental properties might be one of the possible mechanisms contributing to these adverse pregnancy outcomes but there has not been a study evaluating the placental morphological properties of these women. The current study aims to reveal the morphological properties of placenta in women diagnosed with endometriosis and delivered after 20th week of pregnancy.

Interventions

Placentas of women with endometriosis will be morphologically evaluated after delivery The analysis will be held in accordance with the placental classification system defined by G Turowski , L N Berge, L B Helgadottir et al., 2012;33(12):1026-35. This system is clinically oriented, unifying and simple placental pathology classification defining mainly nine major diagnostic categories including normal placenta. Clinical Diagnostic categories are listed below: 1.Placenta with normal morphology,a

Placentas of women with endometriosis will be morphologically evaluated after delivery The analysis will be held in accordance with the placental classification system defined by G Turowski , L N Berge, L B Helgadottir et al., 2012;33(12):1026-35. This system is clinically oriented, unifying and simple placental pathology classification defining mainly nine major diagnostic categories including normal placenta. Clinical Diagnostic categories are listed below: 1.Placenta with normal morphology,according to gestational age 2. Placenta with chorioamnionitis 3. Placenta with villitis and intervillositis 4. Placenta with maternal circulatory disorders (decidual vasculopathy) 5. Placenta with fetal circulatory disorders 6. Placenta with delayed villous maturation 7. Placenta with findings, suggestive of genetic aberration 8. Placenta with implantation disorders 9. Placenta with other lesions Each clinical situation has major defining characteristics defined by the authors. The placentas will be transported to Pathology Department in the same hospital as soon as delivered. The specimens will be fixed and stored until the histopathological examination. Each patient will be questioned about demographic variables but also antenatal problems such as antenatal bleeding in any trimester, placenta previa, small for gestational age, diabetes mellitus etc. But also, each patient will be questioned about the diagnostic procedures held for endometriosis, the stage of endometriosis and the time to pregnancy after the operation etc. The questionnaires for each patient will be filled by the gynecologist by the interview with the patient. A ten minute questionnaire will be held for this purpose.

Sponsors

Asli Yarci Gursoy
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

Histopathologically confirmed diagnosis of endometriosis in a pregnant woman and delivery of the fetus after 20th week of pregnancy whether viable or not.

Exclusion criteria

None

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026