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The Dose and Timing Relationship Between Caffeine and Subsequent Sleep Quantity and Quality

The Dose and Timing Relationship Between Caffeine and Subsequent Sleep Quantity and Quality in Healthy Adults

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621001625864
Enrollment
27
Registered
2021-11-29
Start date
2022-06-03
Completion date
2023-02-28
Last updated
2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This research project is investigating if the amount of caffeine and the time that it is consumed during the day changes the quantity and quality of night-time sleep. The project will involve a low (100mg) and high (400mg) dose of caffeine administered in the morning, afternoon and evening to find out if the effect on sleep changes. Given caffeine is a stimulant, it is expected that sleep will be influenced when more caffeine is consumed closer to bedtime. By investigating different dose and timing combinations, we are aiming to determine if there is a cut-off time for consuming caffeine to avoid poor sleep. This is important as poor sleep is associated with an increased risk of illness, accidents and injuries.

Interventions

Intervention is the administration of caffeine to be taken orally in capsule form. The study is a crossover design where each participant will be randomly exposed to all seven conditions organised using a Latin Square design. Each condition will be separated by a 2 day washout period. Conditions include; Placebo 100mg administered 12 hours prior to bedtime 100mg administered 8 hours prior to bedtime 100mg administered 4 hours prior to bedtime 400mg administered 12 hours prior to bedtime 400mg ad

Intervention is the administration of caffeine to be taken orally in capsule form. The study is a crossover design where each participant will be randomly exposed to all seven conditions organised using a Latin Square design. Each condition will be separated by a 2 day washout period. Conditions include; Placebo 100mg administered 12 hours prior to bedtime 100mg administered 8 hours prior to bedtime 100mg administered 4 hours prior to bedtime 400mg administered 12 hours prior to bedtime 400mg administered 8 hours prior to bedtime 400mg administered 4 hours prior to bedtime Participants will consume three capsules on each experimental day at 12, 8 and 4 hours prior to bedtime. The caffeine capsule will be administered at the timepoint and dose relevant to the condition with the remaining two capsules containing the placebo. All three capsules will contain the placebo for the placebo condition. Saliva samples will be collected using cotton chew swabs to monitor caffeine concentrations and compliance. These will occur on experimental days at 11, 7 and 3 hours prior to bedtime, 5 minutes prior to bedtime and 5 minutes after waking.

Sponsors

Australian Catholic University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)

Eligibility

Sex/Gender
Male
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

Apparently healthy male aged between 18 and 40 years of age No reported medical or sleep condition Daily habitual caffeine consumption <300mg

Exclusion criteria

BMI <18kg/m2 or >26kg/m2 Consumed cigarettes, drugs or medications known to affect sleep in the 3 months prior to study admission Undertaken shift work or transmeridian travel in the 3 months prior to study admission

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 5, 2026