None listed
Conditions
Brief summary
This research project is investigating if the amount of caffeine and the time that it is consumed during the day changes the quantity and quality of night-time sleep. The project will involve a low (100mg) and high (400mg) dose of caffeine administered in the morning, afternoon and evening to find out if the effect on sleep changes. Given caffeine is a stimulant, it is expected that sleep will be influenced when more caffeine is consumed closer to bedtime. By investigating different dose and timing combinations, we are aiming to determine if there is a cut-off time for consuming caffeine to avoid poor sleep. This is important as poor sleep is associated with an increased risk of illness, accidents and injuries.
Interventions
Intervention is the administration of caffeine to be taken orally in capsule form. The study is a crossover design where each participant will be randomly exposed to all seven conditions organised using a Latin Square design. Each condition will be separated by a 2 day washout period. Conditions include; Placebo 100mg administered 12 hours prior to bedtime 100mg administered 8 hours prior to bedtime 100mg administered 4 hours prior to bedtime 400mg administered 12 hours prior to bedtime 400mg administered 8 hours prior to bedtime 400mg administered 4 hours prior to bedtime Participants will consume three capsules on each experimental day at 12, 8 and 4 hours prior to bedtime. The caffeine capsule will be administered at the timepoint and dose relevant to the condition with the remaining two capsules containing the placebo. All three capsules will contain the placebo for the placebo condition. Saliva samples will be collected using cotton chew swabs to monitor caffeine concentrations and compliance. These will occur on experimental days at 11, 7 and 3 hours prior to bedtime, 5 minutes prior to bedtime and 5 minutes after waking.
Sponsors
Study design
Eligibility
Inclusion criteria
Apparently healthy male aged between 18 and 40 years of age No reported medical or sleep condition Daily habitual caffeine consumption <300mg
Exclusion criteria
BMI <18kg/m2 or >26kg/m2 Consumed cigarettes, drugs or medications known to affect sleep in the 3 months prior to study admission Undertaken shift work or transmeridian travel in the 3 months prior to study admission