None listed
Conditions
Brief summary
There has been an emerging interest to guide patient-specific Mechanical Ventilation (MV treatment through model-based approaches. These model-based methods are capable of estimating patient-specific respiratory mechanics, providing clinically useful information to the clinicians to guide MV treatment. Various model-based methods have been studied to aid clinical MV decision making. However, to date, the application of these model-based methods is limited in the clinical environment. In particular, there is little clinical trial evidence supporting the efficacy of these methods. Model-based methods require specific clinical protocols and they can be hard to implement in actual clinical practice. In particular, these protocols may be invasive and potentially harmful. These specific clinical protocols can also affect patients' respiratory mechanics. As a result, there is a lack of clinical patient data to validate the performance of model-based methods. These data are unable to provide the wide information spectrum that is required to investigate the performance of model-based methods. Thus, there is a need for a mechanical ventilation patient database that can be used to investigate the clinical feasibility and efficacy of these model-based methods for MV treatment. To this end, a clinical observation trial is required to recruit MV respiratory failure patients. A data acquisition system will be used to collect MV data automatically when patients have been recruited and consented to the MV trial.
Interventions
This trial is an observational trial to recruit up to 30 patients. All patients admitted to the intensive care unit (ICU) at the IIUM Medical Centre, Malaysia during the study period will be screened for inclusion into the study. Consent from legally-accepted representative will be obtained.
Data collection and clinical protocol
All patients enrolled are to be ventilated using Puritan Bennett PB980 ventilator (Covidien, Boulder, CO, USA). The mechanical ventilation airway pressure and flow of
This trial is an observational trial to recruit up to 30 patients. All patients admitted to the intensive care unit (ICU) at the IIUM Medical Centre, Malaysia during the study period will be screened for inclusion into the study. Consent from legally-accepted representative will be obtained. Data collection and clinical protocol All patients enrolled are to be ventilated using Puritan Bennett PB980 ventilator (Covidien, Boulder, CO, USA). The mechanical ventilation airway pressure and flow of the patients will be collected using a data acquisition device developed by the investigators. 1. The mechanical ventilator settings were not set and will vary depending on attending clinicians. 2. For each patient, the data will be collected for up to 7 days. 3. After 7 days, the data collection is stopped. The following data, subject to availability are collected from the patient recruited into the observational trial. These data will be collected from the hospital record of the patient. 1. Patient gender, height, weight and ethnicity. 2. Patient APACHE III diagnostic code. 3. Primary patient diagnosis contributing to respiratory failure 4. Secondary patient diagnosis contributing to respiratory failure 5. Relevant past medical history e.g. smoking, medication, cardiovascular disease. 6. Chest X-ray score: Murray Index. 7. Mechanical ventilation airway pressure and flow. 8. Fraction of Inspired oxygen. 9. Patient datasheet and arterial blood gases information.
Sponsors
Monash University Malaysia
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients requiring invasive mechanical ventilation (MV) (Intubation or tracheotomy). 2. Patients with PF [partial pressure of oxygen to fraction of inspired oxygen] ratio < 300 mmHg) 3. Arterial line in situ.
Exclusion criteria
1. Patients who are likely to be discontinued from MV within 24 hours. 2. Patients with age less than 16. 3. Any medical condition associated with a clinical suspicion of raised intracranial pressure and/or a measured intracranial pressure equal or more than 20 cmH2O. 4. Patients who have a high spinal cord injury with loss of motor function and/ or have significant weakness from any neurological disease. 5. Patients who are moribund and/or not expected to survive for > 72 hours. 6. Lack of clinical equipoise by intensive care unit (ICU) medical staff managing the patient.
Outcome results
None listed