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Regional vs Intravenous Lidocaine in Determining functional outcome after Lung Surgery (RIDDLE)

Regional vs IV LiDocaine in Determining functional outcome after Lung Surgery (RIDDLE)

Status
Not yet recruiting
Phases
Phase 2
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621001609842
Acronym
RIDDLE
Enrollment
30
Registered
2021-11-26
Start date
2022-03-01
Completion date
2022-07-01
Last updated
2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Substantial persistent pain after major lung surgery remains a significant problem despite new methods of pain control with up to one third of these patients still experiencing pain severe enough to affect their daily living months after lung surgeries. In addition to its effect on the essential daily tasks of living, long term pain is also known to cause mental health problems and lead to long-term opioid dependency further affecting the quality of life of patients and incurring extra cost to the healthcare system. Optimization of the acute pain control immediately after surgery is the single most important factor affecting the development of long-term pain. One of the more recently developed techniques of pain control is a technique called regional anaesthesia whereby local anaesthetic is injected next to the nerves supplying that area of the body with the surgical incision, thereby effectively ‘numbing’ them to reduce the pain felt by the patients. An alternative pain relief technique involves giving a small dose of local anaesthetic, such as lidocaine, directly into the veins of the patient. This method can offer a much more predictable pain relief than a regional anaesthetic technique because it does not require the specialized technical skills to perform and hence it may have a great potential for general use to reduce pain effectively. Nonetheless, administering local anaesthetic agent, such as lidocaine, directly into the blood can still have some rare side effect including drowsiness and changes in heart rhythm and blood pressure. In this study, we aim to compare these two pain relief methods, not only to assess whether one is better than the other in relieving pain, but also whether one is better to allow the patients to recover from surgery.

Interventions

Erector Spinae Plane (ESP) block: An ESP block with catheter will be placed in the operating theatre with 40 mL of 0.2% ropivacaine bolus at the end of operation followed by 0.2% ropivacaine bolus every 4 hours. Catheter will be removed at 24 hours from the time of post anaesthetic care unit (PACU) arrival.

Sponsors

South Metropolitan Health Services
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

• Age >= 18 years old • American Society of Anesthesiologists (ASA) status I, II, III • Elective thoracic surgeries via video assisted thoracic (VAT) approach

Exclusion criteria

• Unable to provide written informed consent • Documented diagnosis of chronic pain or recreational drug use • Known hypersensitivity to amide local anaesthetic • Pregnant or lactating women • Epilepsy • Patients with abnormal liver function test • Patients with arrhythmia, complete bundle branch block, prolonged QT interval • BMI >= 40kg/m2 • Patients admitting to intensive care unit postoperatively

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026