None listed
Conditions
Brief summary
The main aim of this study program will be to develop the current understanding of the chronic stress response to a non-severe burn injury (less than or equal to 20% total body surface area (TBSA)) in adult patients, with the addition of the novel approach of metabolic flexibility assessment to better characterise this response. Specifically, we aim to determine the interaction of the systemic metabolic, inflammatory, musculoskeletal and cardiovascular responses, aiming to present a compete image of the chronic response post non-severe burn injury, as well as the effects of common treatments in the form of surgery and nutritional support. The primary objective of this study will be to determine the state of metabolic flexibility in acute non-severe burned patients (less than or equal to 20% TBSA) across a 12-month period of analysis of recovery at four time points. Secondary objectives of this study will be to analyse the acute stress response of non-severely burned patients across the same 12 month period post injury, looking specifically at metabolic, inflammatory, musculoskeletal and cardiovascular responses, as well as to examine the acute effects of surgical intervention on metabolic rate in non-severely burned patients. We hypothesise that non-severely burned patients will experience a state of metabolic inflexibility throughout their post injury recovery, while also displaying a similar physiological stress response to what is seen in larger burns injuries.
Interventions
This study will examine individuals presenting to the Fiona Stanley Hospital State Adult Burns Unit with less than or equal to 20% body surface area burn injuries, who are expected to undergo at least one surgery during inpatient admission. Participation will involve attendance at face-to-face in both an inpatient and outpatient capacity. Sessions will last approximately 90 minutes, involving a 1 hour follow-up after consumption of a 300ml glucose drink containing 75g of glucose, with observatio
This study will examine individuals presenting to the Fiona Stanley Hospital State Adult Burns Unit with less than or equal to 20% body surface area burn injuries, who are expected to undergo at least one surgery during inpatient admission. Participation will involve attendance at face-to-face in both an inpatient and outpatient capacity. Sessions will last approximately 90 minutes, involving a 1 hour follow-up after consumption of a 300ml glucose drink containing 75g of glucose, with observation of respiratory function post-consumption, as well as collection of a blood sample before and after glucose drink consumption, heart rate measurement via a wearable heart rate monitor, assessment of whole body free fat mass using bioimpedance electrodes, assessment of grip strength, and completion of two questionnaires. Each of these components will take approximately 5 minutes to complete. Assessment of energy expenditure using two devices will occur prior to surgery, which will add approximately 30 minutes to the initial session. The assessments will all be completed by a qualified Exercise Physiologist, except for the blood collection that will be drawn by a resident medical officer or phlebotomy accredited researcher. These observation sessions will occur four times during participation in the study, spanning across a 12-13 month period. These sessions will take place 24-48 hours prior to surgery, 48-72 hours post surgery, 6 weeks post-surgery and 12 months post-surgery.
Sponsors
Murdoch University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Less than or equal to 20% total body surface area burn injury Expected to undergo at least one surgery during their inpatient admission for a burn injury
Exclusion criteria
Facial burns (if unable to form a seal around the mouthpiece for the metabolic assessment) Patients on continuous naso-gastric feeding
Outcome results
None listed