Real time seizure detection in Paediatric Intensive Care patients (RESET child brain) – evaluation of the first quantitative electroencephalography program utilising the full 16 electrode set

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Children with critical illnesses are at high risk (> 20%) of developing seizures and brain injury. Each year, over 10,000 children in Australasia require paediatric critical care unit (PICU) admission. Significant advances in PICU mean more severely ill and injured children now survive, and subsequently go home to the community. However, these children remain at high risk of seizure. Therefore, it is essential that continuous improvements are made that address survivorship and morbidity, especially recognition of patients at risk and preventing further brain injury by monitoring appropriately to save brain function. The measuring of brain activity (electroencephalography/EEG) is the only available form of monitoring brain currents in patients with suspected seizures. Seizures are often invisible otherwise, as children often show no visible signs. Despite improvements in the field, recognising these seizures at the bedside in a timely way is not possible for the treating team. This can have serious effects (high risk of brain dysfunction), and potentially add to long term poor outcome or even death. We will perform a worldwide first cohort study to show that EEG monitoring using automated seizure detection software can lead to accurate and timely seizure detections by bedside clinicians..

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