None listed
Conditions
Brief summary
Pain after tonsillectomy is widely recognised to be not fully controlled by current pain management methods, especially in children. The aim of the study is to find out whether the use of the medication celecoxib will be useful in reducing this pain. The hypothesis is that celecoxib will be safe and effective to manage pain in children after tonsillectomy.
Interventions
Celecoxib at dose of 2mg per kg of body weight, taken twice daily, orally in liquid form for 14 days
AND
Paracetamol at dose of 15mg per kg of body weight, four times a day, orally in liquid form for 14 days
AND
Oxycodone liquid orally, at 0.1mg per kg of body weight, as required (up to four times a day)
These medications will be started on the day of tonsillectomy. Adherence will be monitored by self-report by the patients and/or their guardians on the questionnaires.
Sponsors
Gosford Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
3 Years to 16 Years
Healthy volunteers
No
Inclusion criteria
Patients aged 3-16 years Patients undergoing tonsillectomy with or without adenoidectomy
Exclusion criteria
Patients: *Allergy to non-steroidal anti-inflammatory drugs (NSAIDs), opioids, paracetamol, or sulphonamides *Significant comorbidities unfit for treatment with selected intervention *Already taking NSAIDs, opioids or paracetamol on a regular basis *Patients taking drugs that interact with opioids, paracetamol or NSAIDs *History of peptic ulcers or gastrointestinal bleeding *Females who are pregnant or nursing
Outcome results
None listed