Bioactive glass to prevent post-operative sensitivity of vital teeth bleaching

Effect of Bioactive glass on efficacy and post-operative sensitivity of vital teeth bleaching: Randomized Controlled Clinical Trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12621001334897

Enrollment

Registered

2021-10-05

Start date

2021-11-01

Completion date

2021-12-31

Last updated

2022-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A randomised double-blind placebo-controlled clinical trial aimed to evaluate the effect of bioactive glass 45S5 (BAG) on color change and tooth sensitivity (TS) associated with at-home vital tooth bleaching using 20% carbamide peroxide (CP).

Interventions

The participants will be instructed to apply 20% carbamide peroxide bleaching agent (7 days—04 h each) (Opalescence® PF™, Ultradent Products Inc. USA—20% carbamide peroxide) , delivered by the bleaching custom tray. followed by the application of tooth paste containing Bioactive glass 45S5 (Sensodyne Repair & Protect contains NovaMin® technology) delivered by the bleaching custom tray (7 days—30 min each). The bleaching agent and 45S5 toothpaste will be delivered individually by the participants themselves at their home by the bleaching custom tray. For monitor adherence to the intervention , the researcher will check the bleaching agent and toothpaste containers after 7 days of commencement of intervention to make sure that they are empty.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

1-be at least 18 years old, 2-Have six maxillary anterior teeth with no restorations or carious lesions on their buccal surfaces, 3-colour shade B2 or darker on the shade guide (Vitapan Classical, Vita Zahnfabrik) 4-No history of tooth sensitivity or use of a desensitising agent or desensitising toothpaste in the past 3 months.

Exclusion criteria

1-Previous tooth-bleaching procedures, 2-chronic therapeutic drug history, 3-orthodontic appliance use, 4-periodontal disease or active carious lesions, 5-pregnancy or lactation, 6- severe internal tooth discolouration, 7-allergies to bleaching agent or tray material, 8-smoking.

Outcome results