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A randomised controlled study In women undergoing an induction of labour to determine if the rate of intravenous fluid used impacts upon the duration of labour

Effect of intravenous fluid restriction on the duration of labour in women requiring an induction of labour - a pilot study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621001298808
Enrollment
200
Registered
2021-09-24
Start date
2022-02-19
Completion date
2022-12-04
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a randomised controlled study of women who require an induction of labour, to determine if excess, or inappropriate infusions of fluid given via a vein (intravenous route) is having an effect upon the duration of labour. For this study, women who require an induction of labour will be randomised to receive intravenous fluid at a rate of 40 ml/hr or 250 ml/hr. The duration of labour (in minutes), will be calculated from the commencement of an intravenous infusion of a medication to start labour (a hormone called oxytocin), until the birth of the baby.

Interventions

Arm 1. Women requiring an induction of labour with oxytocin will be randomised to a background infusion of Hartmann's Compound Sodium Lactate (CSL) at 40 ml/hr. The background infusion of Hartmann's CSL will commence at the time of induction of labour, which is defined as the commencement of a separate intravenous infusion of oxytocin. The midwife caring for this patient will be responsible for the commencement of the intravenous line of oxytocin, as well as commencement of the intravenous lin

Arm 1. Women requiring an induction of labour with oxytocin will be randomised to a background infusion of Hartmann's Compound Sodium Lactate (CSL) at 40 ml/hr. The background infusion of Hartmann's CSL will commence at the time of induction of labour, which is defined as the commencement of a separate intravenous infusion of oxytocin. The midwife caring for this patient will be responsible for the commencement of the intravenous line of oxytocin, as well as commencement of the intravenous line of Hartmann's CSL. The background infusion of Hartmann's CSL will cease, at the same time that the intravenous infusion of oxytocin ceases, which is post delivery of the placenta. The third stage of labour will be actively managed by controlled cord traction of the placenta and IM injection of 10 IU of oxytocin into the thigh of the woman. The background infusion of Hartmann's is a continuous infusion, the rate of which is not varied throughout labour. No intravenous fluid boluses of Hartmann's CSL or any other crystalloid is allowed for this study. The appropriate rate of the background infusion of Hartmann's CSL will be verified by an audit of the patient's fluid chart.

Sponsors

Dr Darren Lowen
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject)

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

Pregnant women of 37 weeks or greater gestational age, with a single pregnancy in a cephalic presentation who require an induction of labour

Exclusion criteria

Age < than 18 years Inability to consent Augmentation of labour, rather than induction of labour Pre-eclampsia Previous caesarean section Multiple pregnancy

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 6, 2026