Use of Siemens prototype sequences for Magnetic Resonance Imaging in radiation oncology

As MRI sequence technology is being rapidly developed, there is also growth in prototype sequence development by MRI system vendors. These prototype sequences may provide added clinical benefit to radiotherapy patients. Our department has access to the latest prototype sequence developments through a master research agreement with Siemens Healthineers. These sequences are not yet available as clinical products, however they may prove to be of benefit for some patients, for example improved image quality within a faster imaging time. This is a prospective feasibility and comparison study investigating the use of MRI prototype sequences for radiotherapy patients. Where there is an appropriate prototype sequence available, as determined by the treating clinician, patients already undergoing an MRI as part of their standard care prior to radiotherapy treatment will be recruited to undergo one or more prototype sequences in addition to the standard sequences. The additional prototype sequence(s) will occur after the standard MRI sequences are completed. A single or multiple prototype sequences may be performed as determined by clinician, within a time limit of 15 minutes. All sequences will be performed within the same scanning session. No additional study visits are required. No additional contrast will be given to participants for the purpose of the prototype sequences, they may however require contrast for their standard of care MRI scan. The study sequences will be performed by the Radiation Oncology MRI staff, who will also ensure adherence to the intervention during the scan. The use of these sequences has the potential to provide additional imaging information and highlight particular pathology that improves treatment volume delineation for radiotherapy planning.