None listed
Conditions
Brief summary
The purpose of this study is to determine incidence and clinical outcomes of KRASG12C mutated advanced non-small cell lung cancer patients in Australian cancer therapy centres. Who is it for You may be eligible for this study if you, were diagnosed with advanced NSCLC with the presence of a KRAS G12C mutation between Jan 2018 and Dec 201 , and are a patient at one of the participating sites. Study Details Participants in this study will continue to receive routine clinical care, which will not be impacted by involvement in this study. Enrolled participants will have clinical data collected from one time point from their medical record. Data captured will include patient characteristics, disease characteristics, surgical and or drug treatments administered, survival, and treatment outcomes. Data will be collected at a single point by study personnel from the patient medical record. This study aims to help Oncologist better understand the incidence, demographics, disease characteristics and survival outcomes of KRASG12C mutated advanced NSCLC in Australia. This may ultimately lead to improved standard of care practices which will improve patient outcomes.
Interventions
This study is a secondary data use, non interventional study that aims to determine the prevalence of KRASG12C mutated advanced Non Small Cell Lung Cancer (NSCLC) patients and describe the clinical and tumour characteristics, and treatment outcomes for these patients. Data will be collected retrospectively at a single time point from participating Australian public hospitals and private practice from patients newly diagnosed with advanced NSCLC between 1 Jan 2018 to 31 Dec 2019. There will be
This study is a secondary data use, non interventional study that aims to determine the prevalence of KRASG12C mutated advanced Non Small Cell Lung Cancer (NSCLC) patients and describe the clinical and tumour characteristics, and treatment outcomes for these patients. Data will be collected retrospectively at a single time point from participating Australian public hospitals and private practice from patients newly diagnosed with advanced NSCLC between 1 Jan 2018 to 31 Dec 2019. There will be no additional testing or imaging required above what has been done as part of the patients routine standard of care.
Sponsors
The Walter and Eliza Hall Institute for Medical Research
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with histologically (or cytologically) confirmed advanced non-small cell lung cancer who are diagnosed and referred to a participating centre for consideration of systemic treatment between 1 January 2018 - 31 December 2019 2. Centres that are routinely requesting KRASG12C testing or a panel that includes KRASG12C testing. Molecular data including the presence or absence of KRASG12C mutation must be available 3. Clear documentation of date of tissue diagnosis of advanced NSCLC, clinical presentation, medical co-morbidities, performance status, treatment options delivered, response assessment, therapy duration, reason for treatment discontinuation, site(s) of disease progression and survival data. 4. Patients with any site of metastatic disease including brain metastases
Exclusion criteria
1. Patients who were initially diagnosed and referred for systemic treatment before 1 January 2018 2. Patients with absent key tumour, treatment or outcome data 3. Patients in whom KRAS status is unknown
Outcome results
None listed