None listed
Conditions
Brief summary
This trial aims to determine the clinical effectiveness of erector spinae catheters in pain management for patients undergoing open nephrectomy. Participants will be randomised to two arms: • Intervention (ESP block group): In the ESP (Erector spinae plane) block group, an ultrasound guided ESP block will be performed in the operating theatre while the patient is under general anesthesia followed by the insertion of an erector spinae catheter (ESC). The ESP block group will receive a bolus of 30mL of ropivacaine 0.2% every 4 hours for 24 hours. Our proposed randomised controlled study aims to determine if there is an analgesic benefit of ESP catheter block up to 24 hours in patients undergoing open nephrectomy. Specifically: - procedures and drugs administered: intermittent boluses via Catheter of ropivacaine 0.2%, 30ml bolus every 4 hours Both arms will also be started on an intravenous patient controlled analgesia - who will deliver the intervention: anaesthetists - when the catheter will be placed relative to the nephrectomy procedure: following induction of general anaesthesia. At the beginning of surgery • Control group (Sham ESC group): In the control group, a sham ESC will be used and taped onto the skin on the back. Patients in this group will have their sham catheter connected to a pump to replicate an ESC. Specifically: - what this involves for participants:. a catheter is inserted without administration of anaesthetic, however patients will receive standard patient-controlled analgesia - when the sham procedure will occur relative to the nephrectomy procedure: sham procedure done after induction as well at the start of the operation
Interventions
Our proposed randomised controlled study aims to determine if there is an analgesic benefit of erector spinae plane (ESP) catheter block up to 24 hours in patients undergoing open nephrectomy. Specifically:
- procedures and drugs administered: intermittent boluses via Catheter of ropivacaine 0.2%, 30ml bolus every 4 hours
Both arms will also be started on an intravenous patient controlled analgesia
- who will deliver the intervention: anaesthetists
- when the catheter will be placed relative
Our proposed randomised controlled study aims to determine if there is an analgesic benefit of erector spinae plane (ESP) catheter block up to 24 hours in patients undergoing open nephrectomy. Specifically: - procedures and drugs administered: intermittent boluses via Catheter of ropivacaine 0.2%, 30ml bolus every 4 hours Both arms will also be started on an intravenous patient controlled analgesia - who will deliver the intervention: anaesthetists - when the catheter will be placed relative to the nephrectomy procedure: following induction of general anaesthesia and at the beginning of surgery
Sponsors
Anaesthetic Department RPA Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
• Males and females aged 18- 70 years old with an American society of anaesthesiologist (ASA) physical status score of I to III • Opioid naive • Patients undergoing open nephrectomy • Willing to provide informed consent and to participate and comply with the study requirements
Exclusion criteria
• Patients without prior consent or refusal to participate in the trial • Pregnancy • Unstable cardiac disease • Patients with chronic pain • Patients with coagulation abnormalities • Allergy to local anaesthetics • Skin lesions/infections at site of needle insertion • Systemic infections • Patients weight less than 50kg
Outcome results
None listed