A NEW ZEALAND VERY LOW BIRTHWEIGHT STUDY PROJECT: Cardiovascular Outcomes for Mothers and Babies. Hauora Manawa Mo Nga Whanau.

Intergenerational risk of cardiovascular disease in adults born prematurely and mothers who give birth prematurely: A New Zealand Very Low Birth Weight Longitudinal Cohort Study Project.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12621001173886

Acronym

NZVLBW-COMB

Enrollment

100

Registered

2021-08-31

Start date

2021-09-16

Completion date

2023-12-31

Last updated

2022-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Adults who were born prematurely and mothers who give birth to a preterm baby are at increased risk of cardiovascular disease but neither are included in New Zealand’s risk assessment guidelines. As part of a wider project investigating the impact of premature birth on cardiovascular health we will invite the New Zealand Very Low Birth Weight cohort (born <1500g) and their mothers to have their cardiovascular disease risk assessed and compared to a control group. We will compare cardiovascular risk factors, cardiovascular events, general health and reproductive history in the premature-born NZ VLBW cohort and controls at age 35 years (2021). Cardiovascular events and risk factor trajectory will be compared to cardiovascular risk estimations using health data collected as part of risk factor data collected at 28 years of age using validated calculators (such as NZ PREDICT guidelines). We will also compare cardiovascular disease event rate and all-cause mortality in mothers of the NZ VLBW cohort compared to mothers of controls and calculate and compare five year cardiovascular risk estimates using the NZ PREDICT equations. This will be compared to actual cardiovascular disease events as part of a comprehensive evaluation of cardiovascular health planned in five years’ time. Evaluation for cardiovascular risk in participants will be based upon medical history, blood pressure and anthropometric measurements and blood testing for diabetes and dyslipidemia. This study and our wider research project will help to inform recommendations around cardiovascular risk screening after preterm birth/delivery.

Interventions

This observational study is part of an ongoing longitudinal cohort study investigating outcomes after premature birth at < 1500g. For this project, focusing on cardiovascular health, we will be looking at two generations (mothers who delivered a baby prematurely weighing < 1500g in 1986 and these very low birth weight offspring) Exposure: 1. Premature birth at < 37 weeks gestation and birth weight < 1500g in New Zealand in 1986 (offspring study) 2. Delivery of a baby at <37 weeks and weighing <

Eligibility

Sex/Gender

All

Age

34 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Participants in the population-based New Zealand Very Low Birth Weight Cohort who were born in New Zealand in 1986 at < 37 weeks gestation and weighing <1500g (offspring study) 2. Mothers of participants in the New Zealand Very Low Birth Weight Cohort Study

Exclusion criteria

Decline participation. For control group: Not born in New Zealand in 1986, not born at full term, born small for gestational age, not healthy at birth

Outcome results