A non-randomised study investigating the use of multiparametric magnetic resonance imaging (mpMRI) to develop imaging biomarkers that will be used to predict treatment response following radiotherapy for prostate cancer.

This study collects imaging data in the form of multiparametric magnetic resonance imaging (mpMRI) prior to initiation of radiotherapy and at two time points post radiotherapy. Prostate specific antigen (PSA) blood tests represent the standard measure of treatment response and will be collected at each time point in addition to non-standard blood tests corresponding to collection of imaging data in participants undergoing standard radiotherapy for prostate cancer treatment. The interventions involved in this study are as follows; mpMRI - three additional MRI scans with contrast above what is normal standard of care. The MRI scans will involve the use of the contrast agent Gadovist (dosage given per patient weight will be 0.1 mL/kg, equating to 0.1 mmol/kg) administered intravenously by the treating doctor. The mpMRI scan will be performed by a suitably qualified allied health professional. Scans will be performed at time of radiotherapy planning, and then 6 and 12 months post radiotherapy treatment. Full Blood Count (FBC) and Testosterone will be obtained at three timepoints (prior to radiotherapy planning, and then 6 and 12 months post radiotherapy treatment) which are not standard blood tests for this group of patients. Measurement of Testosterone is also not standard in patents who are not receiving androgen deprivation therapy (ADT). Measures of oxygen level in prostate biopsy tissue collected during standard of care biopsy procedures before treatment will be assessed using immunohistochemistry and will be compared with the mpMRI and blood tests. These immunohistochemistry analyses are not standard of care. Adherence to the study protocol will be recorded in case report forms.