None listed
Conditions
Brief summary
Cognitive remediation is an evidence based therapy to address the thinking problems (e.g. trouble attending, remembering or planning) associated with schizophrenia and related disorders. The exact mechanism of benefit is unclear. This pilot study explores one potential mechanism of effect and that is reward learning ( the rewards that follow learning experiences). Reward learning will be measured before the 12 week intervention and post intervention using clinical measures, pen and paper measures as well as images of the brain that reflect reward learning.
Interventions
This pilot examines whether reward learning is the mechanism of effect for people with schizophrenia spectrum disorder receiving a evidence based therapy, cognitive remediation (CR) that aims to improve cognition
What is CR
CR involves a range of cognitive tasks that focus on attention, memory and planning via drill and practice and strategy based interventions
What is involved in participating in CR
The CR program is twice a week for 1 hour of a computer based program
The first session is face
This pilot examines whether reward learning is the mechanism of effect for people with schizophrenia spectrum disorder receiving a evidence based therapy, cognitive remediation (CR) that aims to improve cognition What is CR CR involves a range of cognitive tasks that focus on attention, memory and planning via drill and practice and strategy based interventions What is involved in participating in CR The CR program is twice a week for 1 hour of a computer based program The first session is face to face with subsequent sessions online with remote facilitation via team software The program is 20 sessions with the time taken to complete 20 sessions usually taking 12 weeks. CR is delivered by trained CR therapists of a range of disciplines The program notes progress and sessions completed as well as therapist keeping a record of attendance
Sponsors
Princess Alexandra Hospital and health service
Study design
Allocation
Non-randomised trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria for the intervention group: Patients of the Metro South Addiction and Mental Health Service Primary diagnosis of schizophrenia spectrum disorder Basic competence in written and spoken English Capacity to consent as advised by the treating team Aged between 18-35 No history of neurological disorders or acquired brain injury. Estimated intelligence quotient >70 Inclusion criteria for healthy control group: No history of a diagnosis of schizophrenia spectrum disorder Basic competence in written and spoken English Capacity to consent as advised by a member of the research team Aged between 18-35 No history of neurological disorders or acquired brain injury. Estimated intelligence quotient >70
Exclusion criteria
• Participants known or have any suspicion that you may have a metallic object in your body. This includes things such as a cardiac pacemaker, cochlear implant, metal IUD (hormonal IUD’s made of plastic are fine), neuro-stimulator, aneurysm clips, non-removable body piercing, history of shrapnel or metal fragments in the eye. • Are pregnant or possibly pregnant (unprotected sex since last menstrual period). • History of claustrophobia. • Have permanent metal braces or a molar retainer. weigh more than 120kg
Outcome results
None listed