“Delirium in Trauma Patients in ICU: a prospective observational cohort study” (DELTA-ICU)

“Investigating the Rate of Delirium in Trauma Patients in ICU: a prospective observational cohort study” (DELTA-ICU)

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12621001052820

Acronym

DELTA-ICU

Enrollment

250

Registered

2021-08-10

Start date

2022-09-30

Completion date

2024-09-20

Last updated

2022-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Delirium is a temporary state of confusion and inattention that occurs in patients who are unwell or have undergone a major injury. Delirium is common and can worsen outcomes. This is an observational study of delirium and the factors associated with delirium in trauma patients admitted to the intensive care unit. We hypothesize that the rate of delirium and the severity in this group of patients will be higher than in other populations. There are certain factors that make the occurrence of delirium more likely and this study aims to quantify the occurrence of these factors . Among them is the quality of sleep, as poor quality sleep has been associated with delirium. To do this we will perform nightly assessments of duration of sleep, ask patients who have been discharged from ICU to answer a questionnaire about their sleep in ICU, and a small group of patients will undergo polysomnography, which is a specific sleep test that provides with in depth information about sleep.

Interventions

Rate of delirium as a percentage of the total number of delirium assessments in ICU trauma patients defined as a positive CAM-ICU test. Of those included in the study, 25 patients, or 10% of the total sample, will be selected at random based on the order that they present with every fifth patient given the opportunity to undergo polysomnography. Polysomnography will involved vital signs as well as muscle tone and electroencephalography performed during sleep. This will occur as a single 8 hour study only once during the patients ICU stay. The polysomnography session will occur between day 2 and day 7 of ICU stay. The person who will administer and interpret the polysomnography for this is is a senior sleep scientist from the Department of Respiratory and Sleep medicine at John Hunter Hospital.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

• 1. Adults (>18 years), • 2. Trauma patients • 3. Admitted to the JHH ICU, • 4. Who can be assessed for delirium twice daily by using the CAM-ICU tool

Exclusion criteria

• 1. Patients under the age of 18 years of age, • 2. Comatose (GCS less than 8), • 3. Patients with confirmed neurological damage from Traumatic Brain Injury (TBI) • 4. Non-English speaking (would not be able to be assessed with the use of CAM-ICU), • 5. Pre-existing cognitive impairment, like dementia, etc.

Outcome results