None listed
Conditions
Brief summary
Stroke is commonly caused by blockage of arteries which carry blood and oxygen to the brain. Thrombolysis, a process of unblocking or recanalizing blood vessels with an injection of tissue plasminogen activator (tPA), has become a standard of care in acute stroke treatment however, only ~40% patients will respond to treatment. This study looks at the variation in blood protein biomarkers involved in thrombolysis including plasmin levels and its relation to the recanalization effect. Adult patients arriving at The Alfred with acute ischemic stroke will be recruited for the study. Informed consent will be obtained from the patient or from the patient’s Medical Treatment Decision Maker (MTDM). Consent will be gained for gaining research blood samples and to use clinical information contained in the hospital electronic patient record for comparative analysis. We aim to recruit at least 40 patients in total. One blood sample, ~10 mL (or 2 teaspoons), will be collected from patients, prior to thrombolysis treatment or on arrival, another one at 1 or 2 hours from the time of thrombolysis or from the time of arrival, then again at 24 hours and 72 hours. Plasmin levels and other immunological parameters will be analysed in these samples, and also in patient’s routine clinical bloods, at the Australian Centre of Blood Diseases on the Alfred campus. The results of this study are expected to expand our understanding on the mechanisms of thrombolysis and potentially improve future stroke therapeutics.
Interventions
Four set of blood samples from patients who presented with ischemic stroke and was thrombolysed will be collected on arrival and 1, 24 and 72 hours post thrombolysis. Four set of blood samples from patients who presented with ischemic stroke but was not thrombolysed will also be collected on arrival and 1, 24 and 72 hours post arrival. No further information will be collected and no follow up is required. The study will recruit patients for up to 2 years with no specified upper limit for total n
Four set of blood samples from patients who presented with ischemic stroke and was thrombolysed will be collected on arrival and 1, 24 and 72 hours post thrombolysis. Four set of blood samples from patients who presented with ischemic stroke but was not thrombolysed will also be collected on arrival and 1, 24 and 72 hours post arrival. No further information will be collected and no follow up is required. The study will recruit patients for up to 2 years with no specified upper limit for total number of patients.
Sponsors
Monash university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients presented to the health service with clinical signs / radiological findings consistent with acute ischemic stroke
Exclusion criteria
Patients presenting with acute haemorrhagic stroke or unsurvivable stroke
Outcome results
None listed