None listed
Conditions
Brief summary
CT coronary angiogram (CTCA) is increasingly used as a non-invasive imaging tool to assess the efficacy of novel therapies on coronary inflammation as well as plaque progression, and it is imperative that we understand the natural history of pericoronary adipose tissue (PCAT) inflammation on serial assessment. The ARISTOCRAT registry is a retrospective and prospective, open-label, multi-centre dynamic observational registry designed to directly assess the natural history of PCAT inflammation, coronary atherosclerosis, characteristics, and determinants of coronary plaque progression.
Interventions
Patients presenting for clinically indicated computed tomography coronary angiogram (CTCA) and had previously underwent CTCA more than 12 months prior are invited to participate in the ARISTOCRAT registry. Once consented, the serial CTCA scanning parameters (scanner, kVP, and reconstruction kernel) will be matched with the prior study. This registry will be conducted conducted for the next 5 years.
We will also collect data regarding participants' traditional cardiovascular risk factors, treat
Patients presenting for clinically indicated computed tomography coronary angiogram (CTCA) and had previously underwent CTCA more than 12 months prior are invited to participate in the ARISTOCRAT registry. Once consented, the serial CTCA scanning parameters (scanner, kVP, and reconstruction kernel) will be matched with the prior study. This registry will be conducted conducted for the next 5 years. We will also collect data regarding participants' traditional cardiovascular risk factors, treatment with lipid-lowering therapy, and fasting lipid profile at the baseline and the serial CTCA study. Patient demographic data and traditional cardiovascular risk factors will be determined from patient questionnaires collected by CT nursing staffs at the time of CCTA scans and by review of electronic medical records. Fasting lipid profile done within 60 days of the CTCA will be collected retrospectively from medical records. These data will be collected via a secured online database in a deidentified manner. No further follow-up will be performed after the CTCA scan.
Sponsors
Monash Cardiovascular Research Centre, Victorian Heart Institute and Monash University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients who had previously underwent clinically indicated CT coronary angiogram at the same institution. 2. Patients who are able to provide written informed consent
Exclusion criteria
1. Heart failure (New York Heart Association (NYHA) class IV) or left ventricular ejection fraction less than or equal to 35%. 2. Inability to provide informed consent. 3. Prior CABG and percutaneous revascularisation. 4. Atrial fibrillation. 5. Contrast allergy. 6. Dialysis or estimated glomerular filtration rate (eGFR) less than 30 ml/min/1.73m².
Outcome results
None listed