None listed
Conditions
Brief summary
Background: Anaemia in pregnancy is a major public health problem globally that has adverse effects on maternal and neonatal health outcomes. The primary cause of anaemia in pregnancy is iron deficiency. Currently, there is a paucity of data on the prevalence of anaemia and iron deficiency in pregnant women in Bangladesh. Objective: To determine the prevalence of anaemia (haemoglobin <11g/dL) and iron deficiency (ferritin <15mg/L) during the second and third trimester (13-32 weeks) of pregnancy in women from three Upazilas (sub-districts) in the Narayanganj district of Bangladesh. Methods: This will be a cross-sectional survey. Pregnant women in their second or third trimester will be identified from the Family Welfare Centre register, which routinely screens women for pregnancy in this setting, and approached to participate in this study. After obtaining informed consent, study staff will collect participant’s demographic information and a blood sample. Up to 1500 pregnant women across 3 Upazilas (sub-districts) of the Narayanganj district of Bangladesh will be screened for anaemia and iron deficiency. The role of this cross-sectional survey in informing future randomised controlled trial in this study setting: This anaemia prevalence survey will also ensure that we have selected an appropriate site for a future randomised clinical trial to determine the effectiveness of treating moderate and severe anaemia during second and third trimester of pregnancy with an intravenous iron formulation, compared to the standard of care of oral iron supplementation. This randomised controlled trial will be registered separately with the ANZCTR. This is a collaborative effort between the International Centre for Diarrhoeal Disease Research, Bangladesh, and the Walter and Eliza Hall Institute (Melbourne, Australia).
Interventions
This will be a an observational study to determine the prevalence of anaemia (haemoglobin <11g/dL) and iron deficiency (ferritin <15mg/L) in pregnant women during the second and third trimester in Bangladesh.
A study physician or technician will collect a 5ml venous blood sample from study participants. Study physicians will also conduct a physical examination checking for pallor, blood pressure, oedema and anthropometric measurements (height, weight, mid-upper arm circumference). Study staff
This will be a an observational study to determine the prevalence of anaemia (haemoglobin <11g/dL) and iron deficiency (ferritin <15mg/L) in pregnant women during the second and third trimester in Bangladesh. A study physician or technician will collect a 5ml venous blood sample from study participants. Study physicians will also conduct a physical examination checking for pallor, blood pressure, oedema and anthropometric measurements (height, weight, mid-upper arm circumference). Study staff will ask participants to complete surveys on their demographic details, socioeconomic status, current and previous pregnancy information, household food security, knowledge, attitudes and practices for anaemia management, and COVID-19 history. Water, sanitation and hygiene (WASH) and Edinburgh Postnatal Depression Scale questionnaires will also be conducted by study staff. This will be a cross-sectional survey and so all the activities outlined above will take place once, during a single assessment per participant. We anticipate this study will be conducted over 3 months.
Sponsors
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)
Eligibility
Sex/Gender
All
Age
14 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Pregnant women in their second or third trimester (13-32 weeks of gestation, dated by Last Menstrual Period). Resident in the study catchment area.
Exclusion criteria
Participants unwilling or unable to provide informed consent.
Outcome results
None listed