None listed
Conditions
Brief summary
The use of nutraceutical supplements to help improve the inflammation in the body is gaining attention. Curcumin has the potential to reduce inflammation with a simultaneous increase in antioxidant capacity. We have observed that supplementation of curcumin reduces the inflammatory markers in older adults at varying amounts; however, the optimal dose remains uncertain. Therefore, the aim of this study is to understand the effect of ingestion of varying doses of curcumin on curcumin availability in blood and its effect on two inflammatory markers.
Interventions
The RECORD study is a controlled, double-blind, crossover intervention trial in healthy older males (50-70 years), designed to understand the anti-inflammatory effects of curcumin following supplementation at varying doses. The aim is to assess the effectiveness of curcumin as an anti-inflammatory agent at doses of 100 mg, 250 mg and 500 mg compared to a control group. Participants will consume one-off dose of curcumin (either placebo, 100 mg, 250 mg or 500 mg) orally at each visit in the form o
The RECORD study is a controlled, double-blind, crossover intervention trial in healthy older males (50-70 years), designed to understand the anti-inflammatory effects of curcumin following supplementation at varying doses. The aim is to assess the effectiveness of curcumin as an anti-inflammatory agent at doses of 100 mg, 250 mg and 500 mg compared to a control group. Participants will consume one-off dose of curcumin (either placebo, 100 mg, 250 mg or 500 mg) orally at each visit in the form of capsules under staff supervision.
Sponsors
Massey University
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver)
Eligibility
Sex/Gender
Male
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
Participants must be healthy males and in the age category of 50-70 years, with a BMI of 18 - 30 kg/m2 and not taking any curcumin supplements (in the last 6 months). They should be non-smokers and available to come to the lab for visits.
Exclusion criteria
Potential participants will be excluded if they have established gall bladder problems, pacemaker implants, severe neurological diseases or seizures. Based on their medication intake from the medical questionnaire, participants will be excluded from the trial if they are taking any medication for type II diabetes mellitus, hypertension and heart conditions; and curcumin supplements (in the past 6 months) to avoid any possible drug interaction with curcumin.
Outcome results
None listed