None listed
Conditions
Brief summary
The aim of the proposed study is to investigate potential associations between oxygen administration during major surgery, and postoperative recovery. The study will be collect data from adult patients having non-cardiothoracic surgery under general anaesthesia at Auckland City Hospital over a 15 year time period, Our hypothesis is that the administration of higher levels of intraoperative oxygen, fraction inspired oxygen (FiO2) = 0.8 is associated with a slower recovery from surgery, compared with non-liberal oxygen therapy (FiO2 < 0.8). The study will look at a number of aspects of postoperative recovery, including the number of days patients spend in their own homes in the first 90 days after surgery, the rate of wound infections after surgery, and other major complications and death following surgery.
Interventions
The exposure of interest is the time-weighted average intraoperative oxygen (FiO2) in patients undergoing surgery and meeting study eligibility criteria within the defined study timeframe (Adult patients admitted to Auckland City Hospital between 01 July 2006 and 30 June 2020 undergoing non-cardiothoracic surgery under general anaesthesia with an operative duration greater than or equal to 120 minutes). Specifically, patients who were exposed to a time-weighted average FiO2 >/= 0.8 (liberal oxyg
The exposure of interest is the time-weighted average intraoperative oxygen (FiO2) in patients undergoing surgery and meeting study eligibility criteria within the defined study timeframe (Adult patients admitted to Auckland City Hospital between 01 July 2006 and 30 June 2020 undergoing non-cardiothoracic surgery under general anaesthesia with an operative duration greater than or equal to 120 minutes). Specifically, patients who were exposed to a time-weighted average FiO2 >/= 0.8 (liberal oxygen therapy) will be compared to those exposed to FiO2 < 0.8. The average time-weighted intraoperative oxygen exposure will be calculated from all available recordings of inspired oxygen fraction from the intraoperative anaesthesia record throughout the entire duration of surgery.
Sponsors
Daniel Frei
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Adult patients (age >/= 18 years) admitted to Auckland City Hospital between 01 July 2006 and 30 June 2020 undergoing non-cardiothoracic surgery under general anaesthesia with an operative duration >/= 120 minutes
Exclusion criteria
Patient data sets will only be included in the study analysis once and databases will be screened for duplicates, which will be removed. For participants with multiple admissions meeting inclusion criteria, the study will consider their first admission within the study period that meets inclusion criteria as the baseline.
Outcome results
None listed