None listed
Conditions
Brief summary
Knee osteoarthritis (OA) is a significant global health condition resulting in pain, reduced function and disability. There is significant heterogeneity within the knee OA population. Structural changes in the knee are not consistently associated with pain, disability and quality of life, with changes in pain sensitisation better accounting for these. This study will determine pain sensitisation in the knee OA population through patient-reported measures, performance-based tests and objective quantitative sensory testing. A prospective longitudinal study involving Ecological Momentary Assessment using a smartphone mobile application will be used to collect momentary biopsychosocial behavioural experiences of those with knee OA. A multivariable prognostic model will then be developed to determine whether baseline pain sensitisation variables predict pain-related outcomes collected through smartphone Ecological Momentary Assessment. Considering pain sensitisation in knee OA could better inform health professionals to improve clinical decision making and therefore improve knee OA outcomes. Additional objectives include comparing Ecological Momentary Assessment outcomes with traditional outcome measures to determine the psychometric properties of Ecological Momentary Assessment methods. A qualitative study consisting of semi-structured focus group interviews will be performed to determine the perceptions of Quantitative Sensory Testing and the acceptability of smartphone-based Ecological Momentary Assessment as a way of collecting pain experiences.
Interventions
Observation of people with pain and knee osteoarthritis longitudinally with follow-up occurring at 2-weeks and 9-weeks.
The baseline assessment includes Quantitative Sensory Testing, Performance Based Testing (30 second Chair test, 6 minute walk test) and completion of Patient-Report Outcome Measures assessing personal characteristics, pain characteristics, functional characteristics, psychosocial characteristics and health/lifestyle measures. This will be performed at the University of Otago
Observation of people with pain and knee osteoarthritis longitudinally with follow-up occurring at 2-weeks and 9-weeks. The baseline assessment includes Quantitative Sensory Testing, Performance Based Testing (30 second Chair test, 6 minute walk test) and completion of Patient-Report Outcome Measures assessing personal characteristics, pain characteristics, functional characteristics, psychosocial characteristics and health/lifestyle measures. This will be performed at the University of Otago School of Physiotherapy with assessment lasting for approximately 90 minutes. Follow-up measurement will occur at two weeks and nine weeks following the baseline assessment. Follow-up measurement involves collecting pain and functional information via patient-reported questionnaires such as the Brief Pain Inventory and the Knee Injury and Osteoarthritis Outcome Score. Measures will also collect information on health-related quality of life, fatigue, physical activity and participation. The two-week follow-up will occur at the University of Otago School of Physiotherapy lasting for approximately 30 minutes. The nine week follow-up will be completed from home with participants being emailed the questionnaires via REDCap. Using a maximum variation sampling method, a group of participants will be invited to participate in 4-5 focus groups made up for 5-6 people. These will consist of semi-structured interviews which will explore the usability and acceptability of smartphone Ecological Momentary Assessment in monitoring knee osteoarthritis pain experiences. Additionally, these focus groups will explore participant perceptions of Quantitative Sensory Testing in knee osteoarthritis. Focus groups will last for approximately one hour at the University of Otago School of Physiotherapy.
Sponsors
Otago Medical Research Foundation
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Those with a diagnosis of knee osteoarthritis who experience knee pain on most days for at least three months will be eligible for inclusion.
Exclusion criteria
Participants will be excluded if they are non-English speaking, are unable to use a smartphone, have an auto-immune condition or other form of inflammatory arthritis, have uncontrolled hypertension, skin conditions, lower limb sensory loss, pregnant or within six months postpartum, have undergone or are scheduled for total knee arthroplasty, have sustained a lower limb injury in the last six months (or still recovery), have a neurological condition, impaired cognition or psychiatric illness.
Outcome results
None listed