Feasibility study for Development of an All-In-One Combined Insulin Cannula and Glucose Sensor as Part of a Automated Patch-Pump Insulin Delivery System in Adults with Type 1 Diabetes

Phase 1 of the study will be completed before commencing on Phase 2. Participants in Phase 1 of the study will be offered the option of participating in Phase 2 of the study - this will be registered in a separate record. Phase 1: 50% insulin bolus for a carbohydrate load - the EOPatch pump will be used during two in-clinic visits (up to 8 hours each including baseline measurements, EOPatch pump insertion/programming and meal challenge) conducted by a doctor and nurse experienced in managing hypo/hyperglycaemia during daylight hours in a major university hospital with a full resuscitation team available if necessary - the EOPatch pump will be inserted by study staff at the start of the in-clinic visit for the meal challenge and removed at the end of each meal challenge - participants will receive (in randomized order) a full insulin bolus (100%) and an underestimated insulin bolus (50%) during the meal challenge with a carbohydrate load (80g high carbohydrate meal) and have monitoring of glycaemia over 6 hours - the first and second meal challenge will be 5-7 days apart (to avoid weekends so as to allow for access to a full resuscitation team, which will be difficult on weekends) EOPatch pump use will be monitored on a regular basis (during the 30-minutely blood glucose checks) to ensure participants are in Auto mode during the meal challenges in the in-clinic visits and pump analytics can be accessed to verify that. Check-in and discharge times for these in-clinic visit will be documented in the case report forms.