None listed
Conditions
Brief summary
There is growing concern about the health impacts of pollution, with increased industrialisation and population growth causing people to work and live in areas with poor air quality.Fruits and vegetables can contain various bioactives that have been reported to impact on airway inflammation, tissue remodelling and immune function. The aim of this pilot study is to determine the safe and effective concentration of ozone to induce temporary lung inflammation and decreased lung function.
Interventions
All participants will be exposed to ozone at a set concentration within a controlled environment for 2 hours to induce acute lung inflammation. During the 2 hours the participants will be asked to perform a moderate cycling exercise at the intensity corresponding to 30-40 L/min of their VEmin. The duration of the cycle exercise will last for 2 hours and will be broken up in intervals of 15 minutes cycling followed by 15 minutes of rest. Each participant will be exposed to a single, steady-state
All participants will be exposed to ozone at a set concentration within a controlled environment for 2 hours to induce acute lung inflammation. During the 2 hours the participants will be asked to perform a moderate cycling exercise at the intensity corresponding to 30-40 L/min of their VEmin. The duration of the cycle exercise will last for 2 hours and will be broken up in intervals of 15 minutes cycling followed by 15 minutes of rest. Each participant will be exposed to a single, steady-state ozone concentration for 2 hours. The ozone concentration within the chamber will be either 0.1, 0.2, and 0.3 ppm. The first cohort of 2 participants will be exposed to 0.1ppm ozone for 2 hours, the next cohort of 2 participants will be exposed to 0.2ppm ozone for 2 hours and so on.
Sponsors
The New Zealand Institute for Plant and Food Research
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy male and female (50/50) non-pregnant individuals 18-40 years of age with normal lung function at baseline will be selected
Exclusion criteria
If they are unwilling or unable to provide informed written consent or comply with the study procedures. • If they have a diagnosed health conditions that impair their lung function (asthma, COPD, fibrosis), diabetes or cardiovascular disease. • If they smoke. If they work in an environment where they are exposed to high levels of occupational respiratory irritants such as ozone or fine particulate matter (eg welders) In addition, participants will also be excluded if they have the following health conditions: (i) blood borne diseases (e.g. hepatitis), (ii) clinically diagnosed high/low blood pressure, (iii) recent bacterial or viral illness or (iv) are taking medication that affects the properties of blood (e.g. blood clotting)
Outcome results
None listed