None listed
Conditions
Brief summary
We aim to prospectively validate a scoring system, the SALT score, in a cohort of patients with anterior skull base tumours undergoing endoscopic endonasal skull base surgery. We will assess how much patients drink and urinate in the days after surgery, as well as routine blood tests, to establish if patients develop diabetes insipidus, a condition where patients are not able to concentrate their urine. We will then assess whether the SALT score was able to predict which patients developed diabetes insipidus.
Interventions
Patients will be subject to standard of care. Patients operated on for anterior skull base pathology will be scored based on imaging characteristics and intraoperative findings. The development of postoperative diabetes insipidus will be recorded in order to prospectively validate a novel predictive scoring system for the development of diabetes insipidus after endoscopic endonasal skull base surgery.
The SALT score, presented here (PMID: 34041659) is a simple scoring system based on suprasell
Patients will be subject to standard of care. Patients operated on for anterior skull base pathology will be scored based on imaging characteristics and intraoperative findings. The development of postoperative diabetes insipidus will be recorded in order to prospectively validate a novel predictive scoring system for the development of diabetes insipidus after endoscopic endonasal skull base surgery. The SALT score, presented here (PMID: 34041659) is a simple scoring system based on suprasellar extension of tumour, craniopharyngioma histology, Age <50y, and intraoperative Kelly grade 3 leak. Imaging is a preoperative volumetric gadolinium enhanced pituitary MRI and volumetric non-contrast CT brain. Both imaging modalities are performed in the week prior to surgery.
Sponsors
Mendel Castle-Kirszbaum
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Anterior skull base pathology designated by a multi-disciplinary team as requiring operative management via an endoscopic endonasal transsphenoidal approach
Exclusion criteria
Preoperative diabetes insipidus
Outcome results
None listed