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A study of patients in cardiac arrest due to ventricular arrhythmias to determine if manual pressure augmentation during defibrillation improves neurological outcome and survival

Investigating the effect of manual pressure augmentation in defibrillation of ventricular fibrillation and ventricular tachycardia on time to return of organised rhythm, neurological outcome and survival of cardiac arrest patients in a shockable rhythm

Status
Terminated
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621000804886
Acronym
AUGMENT-VA
Enrollment
870
Registered
2021-06-25
Start date
2022-01-16
Completion date
2023-01-31
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to determine if hands-on pressure applied by paramedics to patches during defibrillation of patients in cardiac arrest will help to improve survival.

Interventions

Patients in the treatment arm who have a shockable rhythm (VF or VT) will undergo defibrillation of 200J. During shock delivery, paramedics will apply manual maximum pressure to both defibrillation patches while the charge is delivered. If return of spontaneous circulation (ROSC) is not achieved, CPR is continued. Every 2 minutes, a rhythm check will be conducted and if the patient is still in a shockable rhythm, another shock will be given with manual pressure augmentation. This process will be

Patients in the treatment arm who have a shockable rhythm (VF or VT) will undergo defibrillation of 200J. During shock delivery, paramedics will apply manual maximum pressure to both defibrillation patches while the charge is delivered. If return of spontaneous circulation (ROSC) is not achieved, CPR is continued. Every 2 minutes, a rhythm check will be conducted and if the patient is still in a shockable rhythm, another shock will be given with manual pressure augmentation. This process will be repeated each time a shock is given as per the standard resuscitation protocol until ROSC is achieved or resuscitation is ceased. The treatment will be administered by Advanced Life Support and Mobile Intensive Care paramedics and training will be provided via a single 30 minute online learning module and face to face scenario training prior to the trial commencing. Paramedics will also have ongoing access to a trial intranet page with Q&A content and training videos. Trial participation will be voluntary for paramedics and a review of ambulance patient care records will be conducted for each arrest to determine if the intervention was utilised.

Sponsors

Ambulance Victoria
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Adults (18 years of age and over) Confirmed out-of-hospital cardiac arrest In a shockable rhythm (ventricular fibrillation or ventricular tachycardia) at the time of ambulance arrival Suitable for resuscitation to commence/continue by paramedics

Exclusion criteria

Dangers at scene preventing safe defibrillation Trauma Female who is known or suspected to be pregnant Dependent on others for activities of daily living "Not for Resuscitation" or Advanced Care Directive in place Terminal illness

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026