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Resistance exercise and immune health

Investigation of the effect of eight weeks whole body high intensity resistance exercise training on immune measures in healthy males.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12621000720819
Enrollment
7
Registered
2021-06-09
Start date
2021-04-16
Completion date
2021-04-23
Last updated
2021-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

It is widely recognised that high intensity resistance exercise is of great value for increasing athletic performance, but also improving health and longevity. The health benefits associated with resistance training include: a reduction in resting blood pressure; decreased lower back pain; a reduction in pain and discomfort for those suffering from arthritis; a decrease in gastrointestinal transit time; an increase in resting metabolic rate; and improvement in blood lipid profiles. In recent years there have been an increased interest in the study of the effect of high volume endurance activities on immune function. However, the full health related implications of high intensity exercise are not yet fully understood, especially with regard to chronic adaptations to resistance exercise. Successfully analysing immune and myokine (skeletal muscle related cytokine) markers pre- and post-training, with comparison to strength and body compositional measures, will allow us to gain a deeper understanding of how the body adapts to exercise. This will have a potential application in altering the response to exercise with targeted nutritional intervention. We aim to evaluate the effect of 8 weeks of whole body high intensity resistance exercise training on body composition, skeletal muscle function and immune measures.

Interventions

Eight-week High intensity training (HIT) All participants will be required to complete an eight-week HIT programme consisting of two HIT training sessions (45 minutes approximately) a week with at least 72 hours recovery between sessions. Prior to starting each session, participants are required to complete a 5 minute warm-up cycle on a cycle ergometer set at an intensity of 70 watts. Participants will then be asked to complete a full body high intensity weight circuit, training with maximal

Eight-week High intensity training (HIT) All participants will be required to complete an eight-week HIT programme consisting of two HIT training sessions (45 minutes approximately) a week with at least 72 hours recovery between sessions. Prior to starting each session, participants are required to complete a 5 minute warm-up cycle on a cycle ergometer set at an intensity of 70 watts. Participants will then be asked to complete a full body high intensity weight circuit, training with maximal intensity on each given exercise, with a rest of 60-90 seconds between each exercise. Maximal intensity is assessed in each exercise by reaching momentary muscular failure, whereby another repetition becomes impossible for the participant. The exercises will be carried out in the following order : 1. Squat: 2. Leg extension: 3. Leg curl: 4. Standing calf raise: 5. Pull down 6. Bench press: 7. Seated row: 8. Shoulder press: 9. Bicep curl: 10. Tricep extension: The exercise training sessions will be overseen by Dr Andrew Carroll, a researcher with more than 10 years experience. Exercise sessions will be in person 2x per week at Massey University, Palmerston North.

Sponsors

Dr Jocelyn Eason
Lead SponsorIndividual

Study design

Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Educational / counselling / training
Masking
Open (masking not used)

Eligibility

Sex/Gender
Male
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy individuals (male) 18-40 years, who are not following any specialised diets and not currently undertaking regular resistance exercise. Participants will be required to complete a health questionnaire and provide written consent for this study.

Exclusion criteria

Participants will be excluded if they are unwilling or unable to provide informed written consent or comply with study procedures. All participants will be in good physical health and. Participants will also be excluded if they have (i) blood borne diseases (e.g., hepatitis), (ii) clinically diagnosed high/low blood pressure, (iii) recent bacterial or viral illness, (iv) are taking any mediation that affects the properties of blood (e.g. blood clotting) (iv) any recent musculoskeletal injuries within the past 3 months).

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026