None listed
Conditions
Brief summary
This study aims to determine if there is any association between endometrial cystic spaces identified on ultrasound and the incidence of endometrial hyperplasia (abnormal uterine cell growth that may or may not become cancerous), and the incidence endometrial cancer in women with abnormal uterine bleeding. Who is it for? You may be eligible for this study if you are aged 30 or older, have been diagnosed with abnormal uterine bleeding and you have been referred to the Royal Women's Hospital (Melbourne) for a hysteroscopy dilatation and curettage (HDC) procedure, or an endometrial biopsy. Study details All participants who choose to enrol in this study will be asked to complete a 15 minute online health questionnaire, and undergo a transvaginal pelvic ultrasound to determine the presence or absence of endometrial cysts. The ultrasound scan will be performed or directly supervised by a senior ultrasound specialist. Where possible this visit will be timed to occur on the same day as the hysteroscopy to avoid a further trip to hospital. It is hoped this research may improve health outcomes by allowing for early identification of endometrial hyperplasia or cancer, which could have additional positive impacts on the future management of women with endometrial cysts.
Interventions
This study looks at the association between endometrial cystic spaces found on ultrasound in women with abnormal uterine bleeding and either endometrial hyperplasia or endometrial cancer.
The consenting participants will answer a short (15 minute) online health questionnaire and undergo a transvaginal pelvic ultrasound (30 minutes) to determine the presence or absence of endometrial cysts. The scan will be performed or directly supervised by a senior O&G ultrasound specialist. Where possible th
This study looks at the association between endometrial cystic spaces found on ultrasound in women with abnormal uterine bleeding and either endometrial hyperplasia or endometrial cancer. The consenting participants will answer a short (15 minute) online health questionnaire and undergo a transvaginal pelvic ultrasound (30 minutes) to determine the presence or absence of endometrial cysts. The scan will be performed or directly supervised by a senior O&G ultrasound specialist. Where possible this will be timed to occur on the same day as their endometrial sampling to avoid a further trip to hospital. Participants will then have endometrial sampling (hysteroscopy dilatation and curettage) which is routinely a day procedure.
Sponsors
The Royal Women's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Women aged 30 years old and above • With abnormal uterine bleeding o Defined by any of the following: Postmenopausal bleeding Intermenstrual bleeding Postcoital bleeding with a normal cervical screening test (CST) Bleeding less than every 22 days Heavy or prolonged bleeding • And waitlisted for HDC or endometrial biopsy for investigation of abnormal uterine bleeding
Exclusion criteria
• Inability to consent: no capacity or does not fully comprehend consent information • Known current or previous history of endometrial hyperplasia or endometrial cancer • Endometrial sampling or intrauterine manipulation performed less than 28 days prior to recruitment (due to potential alteration of endometrium and impact on subsequent ultrasound findings) • Non english speaking background
Outcome results
None listed